PMID- 29113316
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 46
DP  - 2017 Oct 6
TI  - Efficacy of sub-threshold focused ultrasound irradiation against pancreatic 
      cancer xenografts evaluated using magnetic resonance imaging.
PG  - 80453-80460
LID - 10.18632/oncotarget.19241 [doi]
AB  - We investigated the efficacy and optimal period for using magnetic resonance 
      imaging (MRI) to detect effects of sub-threshold focused ultrasound (FUS) 
      irradiation. Nude mice bearing pancreatic cancer xenografts were subjected to MRI 
      and pathology examnation before, and 24 h, 48 h, 2 weeks after irradiation, which 
      were used to evaluate therapeutic effects of FUS. Tumor volumes were lower 
      post-treatment than control group (P < 0.05). The T1WI turbo spin echo (T1WI-TSE) 
      sequence was similar signal before and after treatment. On T1 enhanced scanning 
      sequence (T1WI-SPIR) imaging, ablation lesions appeared as patchy areas of low 
      signal after 24 h and 48 h. After 2 weeks, the ablation lesions contained low 
      signal areas with clear borders. Hematoxylin and eosin (HE) staining revealed 
      small vessels at ablation lesions with no obvious boundary between cell injury 
      areas and normal tumor cells areas in early-stage, while revealed obvious 
      boundaries 2 weeks post-treatment. Terminal deoxynucleotidyl 
      transferase-modified, dUTP nick-end labeling (TUNEL) staining showed cell 
      apoptosis in early-stage, and revealed reduced apoptotic cells and increased 
      necrotic cell areas 2 weeks later. These findings indicate sub-threshold FUS 
      induces pancreatic cancer cell apoptosis and inhibits tumor growth. 
      Contrast-enhanced MRI delineated the ablation lesions better 2 weeks 
      post-treatment than early stage.
FAU - Wang, Rui
AU  - Wang R
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Guo, Qian
AU  - Guo Q
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Chen, Yini
AU  - Chen Y
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Gao, Yihui
AU  - Gao Y
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Wu, Lei
AU  - Wu L
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Hu, Bing
AU  - Hu B
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
FAU - Jiang, Lixin
AU  - Jiang L
AD  - Department of Ultrasonography, Shanghai Jiaotong University Affiliated No. 6 
      Hospital, Shanghai 200233, PR China.
AD  - Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, PR China.
LA  - eng
PT  - Journal Article
DEP - 20170714
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5655211
OTO - NOTNLM
OT  - MRI
OT  - focused ultrasound ablation
OT  - nude mice
OT  - pancreatic cancer
OT  - xenografts
COIS- CONFLICTS OF INTEREST The authors declare that there are no conflicts of 
      interest.
EDAT- 2017/11/09 06:00
MHDA- 2017/11/09 06:01
PMCR- 2017/10/06
CRDT- 2017/11/09 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/06/11 00:00 [accepted]
PHST- 2017/11/09 06:00 [entrez]
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2017/11/09 06:01 [medline]
PHST- 2017/10/06 00:00 [pmc-release]
AID - 19241 [pii]
AID - 10.18632/oncotarget.19241 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jul 14;8(46):80453-80460. doi: 10.18632/oncotarget.19241. 
      eCollection 2017 Oct 6.