PMID- 29113496 OWN - NLM STAT- MEDLINE DCOM- 20190621 LR - 20220317 IS - 1365-2060 (Electronic) IS - 0785-3890 (Linking) VI - 50 IP - 1 DP - 2018 Feb TI - Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study. PG - 74-82 LID - 10.1080/07853890.2017.1399446 [doi] AB - OBJECTIVES: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood. MATERIALS AND METHODS: This was a 31-year follow-up study of 2300 participants aged 3-18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life. RESULTS: High serum 25OHD levels in youth and also mean values from youth to adulthood were associated with reduced risk of developing T2DM in adulthood (odds ratio, 95% confidence interval= 0.73, 0.57-0.95 and 0.65, 0.51-0.84, respectively, for each SD increment in 25OHD). Compared to Q1, a dose-dependent negative association was observed across other quartiles of youth 25OHD, while the strongest association was found in the Q3 for the mean 25OHD levels. Neither youth nor the mean 25OHD was associated with IFG. CONCLUSIONS: High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood. Key Messages High serum 25OHD levels in youth, and between youth and adulthood, were associated with a lower risk of T2DM in adulthood. Each SD (15.2 nmol/L) increment in youth serum 25OHD levels was associated with a 26% reduction in odds for T2DM, which was independent of a number of confounding variables and other risk factors for T2DM. A similar magnitude of association was observed for the long-term 25OHD levels between youth and adulthood. These findings suggest a potentially simple and cost-effective strategy for reducing adulthood risk of T2DM starting in an earlier stage of life - improving and maintaining vitamin D status throughout youth and early adulthood. FAU - Wu, Feitong AU - Wu F AUID- ORCID: 0000-0003-3753-974X AD - a Menzies Institute for Medical Research , University of Tasmania , Hobart , TAS , Australia. FAU - Juonala, Markus AU - Juonala M AD - b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland. AD - c Department of Medicine , University of Turku and Division of Medicine, Turku University Hospital , Turku , Finland. FAU - Pitkanen, Niina AU - Pitkanen N AD - b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland. FAU - Jula, Antti AU - Jula A AD - d National Institute for Health and Welfare , Turku , Finland. FAU - Lehtimaki, Terho AU - Lehtimaki T AD - e Department of Clinical Chemistry, Fimlab Laboratories, and Faculty of Medicine and Life Sciences , University of Tampere , Tampere , Finland. FAU - Sabin, Matthew A AU - Sabin MA AD - f Murdoch Children's Research Institute, Royal Children's Hospital , and Department of Paediatrics , University of Melbourne , Melbourne , VIC , Australia. FAU - Pahkala, Katja AU - Pahkala K AD - b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland. AD - g Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health , University of Turku , Turku , Finland. FAU - Hutri-Kahonen, Nina AU - Hutri-Kahonen N AD - h Department of Pediatrics , University of Tampere and Tampere University Hospital , Tampere , Finland. FAU - Kahonen, Mika AU - Kahonen M AD - i Department of Clinical Physiology , Tampere University Hospital and University of Tampere , Tampere , Finland. FAU - Laitinen, Tomi AU - Laitinen T AD - j Department of Clinical Physiology and Nuclear Medicine , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland. FAU - Viikari, Jorma S A AU - Viikari JSA AD - c Department of Medicine , University of Turku and Division of Medicine, Turku University Hospital , Turku , Finland. FAU - Magnussen, Costan G AU - Magnussen CG AD - a Menzies Institute for Medical Research , University of Tasmania , Hobart , TAS , Australia. AD - b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland. FAU - Raitakari, Olli T AU - Raitakari OT AD - b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland. AD - k Department of Clinical Physiology and Nuclear Medicine , Turku University Hospital , Turku , Finland. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20171107 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Cohort Studies MH - Diabetes Mellitus, Type 2/*blood/*epidemiology/etiology/prevention & control MH - Fasting MH - Female MH - Finland/epidemiology MH - Humans MH - Incidence MH - Male MH - Prediabetic State/*blood/epidemiology MH - Risk Factors MH - Vitamin D/*analogs & derivatives/*blood OTO - NOTNLM OT - 25-hydroxyvitamin D OT - impaired fasting glucose OT - type 2 diabetes mellitus OT - youth EDAT- 2017/11/09 06:00 MHDA- 2019/06/22 06:00 CRDT- 2017/11/09 06:00 PHST- 2017/11/09 06:00 [pubmed] PHST- 2019/06/22 06:00 [medline] PHST- 2017/11/09 06:00 [entrez] AID - 10.1080/07853890.2017.1399446 [doi] PST - ppublish SO - Ann Med. 2018 Feb;50(1):74-82. doi: 10.1080/07853890.2017.1399446. Epub 2017 Nov 7.