PMID- 29113502
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 46
IP  - 8
DP  - 2018 Dec
TI  - Osteogenic and antibacterial properties of vancomycin-laden mesoporous 
      bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects.
PG  - 1935-1947
LID - 10.1080/21691401.2017.1396997 [doi]
AB  - Chronic osteomyelitis and infected bone defects are substantial challenges faced 
      by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous 
      bioactive glass (MBG) to form a local antibiotic delivery system and then a bone 
      tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) 
      (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water 
      contact angle analysis suggested that the MBG-incorporated PLGA scaffold 
      exhibited controlled degradability, stabilizing the pH of the surrounding 
      environment and improved the hydrophilicity. Moreover, the presence of MBG 
      provides a well-interconnected pore structure, to which human bone marrow-derived 
      mesenchymal stem cells can attach, spread and proliferate, promoting upregulation 
      of the expression of osteogenic markers. Thus, MBG/PLGA scaffolds exhibit better 
      cytocompatibility and osteoblastic difierentiation properties compared with pure 
      PLGA scaffolds. Vancomycin-loaded scaffolds have been found to yield sustained 
      release that lasts for more than eight weeks in vitro. We tested the 
      antibacterial performance of vancomycin-loaded scaffolds against Staphylococcus 
      aureus, the most common bacteria isolated from infected bone. In vitro 
      experiments demonstrated that loading vancomycin onto the scaffold promoted 
      antibacterial activity and inhibited biofilm formation without deleterious effect 
      on cytocompatibility. In conclusion, the novel inorganic-organic composites are 
      considered potential materials for the treatment of infected bone defects.
FAU - Cheng, Tao
AU  - Cheng T
AD  - a Department of Orthopaedic Surgery , Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital , Shanghai , China.
FAU - Qu, Haiyun
AU  - Qu H
AD  - b Analysis and Testing Center for Inorganic Materials , Shanghai Institute of 
      Ceramics, Chinese Academy of Sciences , Shanghai , China.
FAU - Zhang, Guoyou
AU  - Zhang G
AD  - c Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
FAU - Zhang, Xianlong
AU  - Zhang X
AD  - a Department of Orthopaedic Surgery , Shanghai Jiao Tong University Affiliated 
      Sixth People's Hospital , Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20171107
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bioglass)
RN  - 0 (Delayed-Action Preparations)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - *Anti-Bacterial Agents/chemistry/pharmacokinetics/pharmacology
MH  - Biofilms/drug effects/growth & development
MH  - Bone Regeneration/*drug effects
MH  - *Ceramics/chemistry/pharmacokinetics/pharmacology
MH  - Delayed-Action Preparations/chemistry/pharmacokinetics/pharmacology
MH  - Humans
MH  - Osteogenesis/*drug effects
MH  - Osteomyelitis/*drug therapy/metabolism/pathology
MH  - *Polylactic Acid-Polyglycolic Acid 
      Copolymer/chemistry/pharmacokinetics/pharmacology
MH  - Porosity
MH  - Staphylococcal Infections/*drug therapy/metabolism/pathology
MH  - Staphylococcus aureus/*physiology
MH  - *Vancomycin/chemistry/pharmacokinetics/pharmacology
OTO - NOTNLM
OT  - Mesoporous bioactive glass
OT  - antimicrobial
OT  - infection
OT  - osteogenesis
OT  - osteomyelitis
EDAT- 2017/11/09 06:00
MHDA- 2019/03/21 06:00
CRDT- 2017/11/09 06:00
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2017/11/09 06:00 [entrez]
AID - 10.1080/21691401.2017.1396997 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1935-1947. doi: 
      10.1080/21691401.2017.1396997. Epub 2017 Nov 7.