PMID- 29113519
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181106
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 53
IP  - 5
DP  - 2018 May
TI  - Does the low FODMAP diet improve symptoms of radiation-induced enteropathy? A 
      pilot study.
PG  - 541-548
LID - 10.1080/00365521.2017.1397186 [doi]
AB  - RATIONALE: Patients with radiation-induced enteropathy (RE) after cancer 
      treatment show similar symptoms as patients with irritable bowel syndrome (IBS). 
      The low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols 
      (FODMAP) diet (LFD) is a widespread management strategy for IBS. We aimed to 
      investigate if there may be a positive effect of LFD on symptoms and 
      health-related quality of life (HRQOL) in patients with RE. METHODS: In an open 
      non-controlled pilot study, 11 patients (all female) with RE-related IBS symptoms 
      were recruited largely based on own initiative. All followed LFD for four weeks. 
      IBS Severity Scoring System (IBS-SSS) and IBS Symptom Questionnaire (IBS-SQ) were 
      used to assess symptoms. Short Form Nepean Dyspepsia Index (SF-NDI) and 12-item 
      Short Form Health Survey (SF-12) evaluated HRQOL. A three day food record was 
      used to estimate baseline intake of FODMAPs and to reveal dietary changes. 
      RESULTS: FODMAP intake was successfully reduced, although LFD was found a 
      burdensome intervention. IBS symptoms improved significantly based on mean total 
      score of IBS-SSS and IBS-SQ, which changed from 310.2 +/- 60.7 to 171.4 +/- 107.2 
      (p = .001) and 27.4 +/- 4.1 to 15.7 +/- 10.1 (p = .002). HRQOL improved based on 
      SF-NDI total score (30.5 +/- 9.4 to 18.3 +/- 8.2, p = .001) and based on mental 
      (p = .047) and physical (p = .134) score of SF-12. Main additional dietary 
      changes were reduced intake of energy, carbohydrates, and fiber. CONCLUSION: Our 
      findings from this small-scaled pilot study indicate that the LFD may alleviate 
      symptoms and improve HRQOL in patients with RE. Further controlled studies with 
      larger sample size should be conducted to verify our results and hopefully enable 
      implementation of LFD as a future part of the management strategy for RE.
FAU - Larsen, Trine
AU  - Larsen T
AD  - a Center for Nutrition, Department of Clinical Medicine , University of Bergen , 
      Bergen , Norway.
FAU - Hausken, Trygve
AU  - Hausken T
AUID- ORCID: 0000-0001-7080-8396
AD  - a Center for Nutrition, Department of Clinical Medicine , University of Bergen , 
      Bergen , Norway.
AD  - b Section of Gastroenterology, Department of Medicine , Haukeland University 
      Hospital , Bergen , Norway.
AD  - c National Centre of Functional Gastrointestinal Disorders , Haukeland University 
      Hospital , Bergen , Norway.
FAU - Otteraaen Ystad, Synne
AU  - Otteraaen Ystad S
AD  - a Center for Nutrition, Department of Clinical Medicine , University of Bergen , 
      Bergen , Norway.
AD  - c National Centre of Functional Gastrointestinal Disorders , Haukeland University 
      Hospital , Bergen , Norway.
FAU - Hovdenak, Nils
AU  - Hovdenak N
AD  - a Center for Nutrition, Department of Clinical Medicine , University of Bergen , 
      Bergen , Norway.
FAU - Mueller, Bernd
AU  - Mueller B
AD  - d Hyperbaric Medical Unit , Haukeland University Hospital , Bergen , Norway.
FAU - Lied, Gulen Arslan
AU  - Lied GA
AD  - a Center for Nutrition, Department of Clinical Medicine , University of Bergen , 
      Bergen , Norway.
AD  - b Section of Gastroenterology, Department of Medicine , Haukeland University 
      Hospital , Bergen , Norway.
AD  - c National Centre of Functional Gastrointestinal Disorders , Haukeland University 
      Hospital , Bergen , Norway.
LA  - eng
PT  - Journal Article
DEP - 20171107
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Disaccharides)
RN  - 0 (Monosaccharides)
RN  - 0 (Oligosaccharides)
SB  - IM
CIN - Scand J Gastroenterol. 2018 Mar;53(3):377-378. PMID: 29433349
MH  - Adult
MH  - *Diet
MH  - Disaccharides
MH  - Female
MH  - Humans
MH  - Intestinal Diseases/*diet therapy
MH  - Irritable Bowel Syndrome
MH  - Male
MH  - Middle Aged
MH  - Monosaccharides
MH  - Neoplasms/*radiotherapy
MH  - Norway
MH  - Oligosaccharides
MH  - Pilot Projects
MH  - Quality of Life
MH  - Radiation Injuries/*diet therapy
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - FODMAP
OT  - cancer
OT  - gut health
OT  - irritable bowel syndrom
OT  - radiation damage
OT  - radiation-induced enteropathy
EDAT- 2017/11/09 06:00
MHDA- 2018/11/07 06:00
CRDT- 2017/11/09 06:00
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2017/11/09 06:00 [entrez]
AID - 10.1080/00365521.2017.1397186 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2018 May;53(5):541-548. doi: 
      10.1080/00365521.2017.1397186. Epub 2017 Nov 7.