PMID- 29113700
OWN - NLM
STAT- MEDLINE
DCOM- 20190118
LR  - 20220408
IS  - 1879-0097 (Electronic)
IS  - 0109-5641 (Linking)
VI  - 34
IP  - 2
DP  - 2018 Feb
TI  - High performance dental resin composites with hydrolytically stable monomers.
PG  - 228-237
LID - S0109-5641(17)30330-5 [pii]
LID - 10.1016/j.dental.2017.10.007 [doi]
AB  - OBJECTIVE: The objectives of this project were to: 1) develop strong and durable 
      dental resin composites by employing new monomers that are hydrolytically stable, 
      and 2) demonstrate that resin composites based on these monomers perform 
      superiorly to the traditional bisphenol A glycidyl dimethacrylate/triethylene 
      glycol dimethacrylate (Bis-GMA/TEGDMA) composites under testing conditions 
      relevant to clinical applications. METHODS: New resins comprising hydrolytically 
      stable, ether-based monomer, i.e., triethylene glycol divinylbenzyl ether 
      (TEG-DVBE), and urethane dimethacrylate (UDMA) were produced via 
      composition-controlled photo-polymerization. Their composites contained 67.5wt% 
      of micro and 7.5wt% of nano-sized filler. The performances of both copolymers and 
      composites were evaluated by a battery of clinically-relevant assessments: degree 
      of vinyl conversion (DC: FTIR and NIR spectroscopy); refractive index (n: optical 
      microscopy); elastic modulus (E), flexural strength (F) and fracture toughness 
      (K(IC)) (universal mechanical testing); Knoop hardness (HK; indentation); water 
      sorption (W(sp)) and solubility (W(su)) (gravimetry); polymerization shrinkage 
      (S(v); mercury dilatometry) and polymerization stress (tensometer). The 
      experimental UDMA/TEG-DVBE composites were compared with the Bis-GMA/TEGDMA 
      composites containing the identical filler contents, and with the commercial 
      micro hybrid flowable composite. RESULTS: UDMA/TEG-DBVE composites exhibited n, 
      E, W(sp), W(su) and S(v) equivalent to the controls. They outperformed the 
      controls with respect to F (up to 26.8% increase), K(IC) (up to 27.7% increase), 
      modulus recovery upon water sorption (full recovery vs. 91.9% recovery), and 
      stress formation (up to 52.7% reduction). In addition, new composites showed up 
      to 27.7% increase in attainable DC compared to the traditional composites. 
      Bis-GMA/TEGDMA controls exceeded the experimental composites with respect to only 
      one property, the composite hardness. Significantly, up to 18.1% lower HK values 
      in the experimental series (0.458GPa) were still above the clinically required 
      threshold of approx. 0.4GPa. SIGNIFICANCE: Hydrolytic stability, 
      composition-controlled polymerization and the overall enhancement in 
      clinically-relevant properties of the new resin composites make them viable 
      candidates to replace traditional resin composites as a new generation of strong 
      and durable dental restoratives.
CI  - Copyright (c) 2017 The Academy of Dental Materials. All rights reserved.
FAU - Wang, Xiaohong
AU  - Wang X
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA.
FAU - Huyang, George
AU  - Huyang G
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA.
FAU - Palagummi, Sri Vikram
AU  - Palagummi SV
AD  - Biomaterials Group, Biosystems and Biomaterials Division, National Institute of 
      Standards and Technology, Gaithersburg, MD 20899, USA.
FAU - Liu, Xiaohui
AU  - Liu X
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA.
FAU - Skrtic, Drago
AU  - Skrtic D
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA.
FAU - Beauchamp, Carlos
AU  - Beauchamp C
AD  - Materials Science and Engineering Division, National Institute of Standards and 
      Technology, Gaithersburg, MD 20899, USA.
FAU - Bowen, Rafael
AU  - Bowen R
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA.
FAU - Sun, Jirun
AU  - Sun J
AD  - Dr. Anthony Volpe Research Center, American Dental Association Foundation, 
      Gaithersburg, MD 20899, USA. Electronic address: jsun@nist.gov.
LA  - eng
GR  - U01 DE023752/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171104
PL  - England
TA  - Dent Mater
JT  - Dental materials : official publication of the Academy of Dental Materials
JID - 8508040
RN  - 0 (Acrylic Resins)
RN  - 0 (Composite Dental Resin)
RN  - 0 (Composite Resins)
RN  - 0 (Methacrylates)
RN  - 0 (Polymethacrylic Acids)
RN  - 0 (Polyurethanes)
RN  - 125523-74-2 (urethane dimethacrylate luting resin)
RN  - 14I47YJ5EY (triethylene glycol dimethacrylate)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
MH  - Acrylic Resins/*chemistry
MH  - Composite Resins/*chemistry
MH  - Elastic Modulus
MH  - Esthetics, Dental
MH  - Hardness
MH  - Hydrolysis
MH  - Materials Testing
MH  - Methacrylates/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Polymerization
MH  - Polymethacrylic Acids/*chemistry
MH  - Polyurethanes/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Spectroscopy, Near-Infrared
MH  - Surface Properties
OTO - NOTNLM
OT  - Composition controlled polymerization
OT  - Dental resin composites
OT  - Dental resins
OT  - Hydrolytically stable resins
OT  - Polymerization stress
EDAT- 2017/11/09 06:00
MHDA- 2019/01/19 06:00
CRDT- 2017/11/09 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/10/05 00:00 [revised]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2019/01/19 06:00 [medline]
PHST- 2017/11/09 06:00 [entrez]
AID - S0109-5641(17)30330-5 [pii]
AID - 10.1016/j.dental.2017.10.007 [doi]
PST - ppublish
SO  - Dent Mater. 2018 Feb;34(2):228-237. doi: 10.1016/j.dental.2017.10.007. Epub 2017 
      Nov 4.