PMID- 29113832
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 41
DP  - 2018 Jan
TI  - Connecting chaperone-mediated autophagy dysfunction to cellular senescence.
PG  - 34-41
LID - S1568-1637(17)30235-0 [pii]
LID - 10.1016/j.arr.2017.11.001 [doi]
AB  - Chaperone-mediated autophagy (CMA) is one of the main pathways of the 
      lysosome-autophagy proteolytic system. It regulates different cellular process 
      through the selective degradation of cytosolic proteins. In ageing, the function 
      of CMA is impaired causing an inefficient stress response and the accumulation of 
      damaged, oxidized or misfolded proteins, which is associated with numerous 
      age-related diseases. Deficient protein degradation alters cellular proteostasis 
      and activates signaling pathways that culminate in the induction of cellular 
      senescence, whose accumulation is a typical feature of ageing. However, the 
      relationship between CMA activity and cellular senescence has been poorly 
      studied. Here, we review and integrate evidence showing that CMA dysfunction 
      correlates with the acquisition of many hallmarks of cellular senescence and 
      propose that loss of CMA function during aging promotes cellular senescence.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Moreno-Blas, Daniel
AU  - Moreno-Blas D
AD  - Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, 
      National Autonomous University of Mexico (UNAM), Mexico City, Mexico. Electronic 
      address: dmoreno@email.ifc.unam.mx.
FAU - Gorostieta-Salas, Elisa
AU  - Gorostieta-Salas E
AD  - Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, 
      National Autonomous University of Mexico (UNAM), Mexico City, Mexico. Electronic 
      address: elisag@email.ifc.unam.mx.
FAU - Castro-Obregon, Susana
AU  - Castro-Obregon S
AD  - Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, 
      National Autonomous University of Mexico (UNAM), Mexico City, Mexico. Electronic 
      address: scastro@ifc.unam.mx.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171104
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
RN  - 0 (Molecular Chaperones)
MH  - Animals
MH  - Autophagy/*physiology
MH  - Cellular Senescence/*physiology
MH  - DNA Damage/physiology
MH  - Humans
MH  - Lysosomes/physiology
MH  - Metabolic Networks and Pathways/physiology
MH  - Molecular Chaperones/*metabolism
MH  - Oxidation-Reduction
MH  - Proteolysis
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - *Aging
OT  - *Cellular senescence
OT  - *Chaperone-mediated autophagy
OT  - *Macroautophagy
OT  - *Proteostasis
EDAT- 2017/11/09 06:00
MHDA- 2019/08/06 06:00
CRDT- 2017/11/09 06:00
PHST- 2017/09/21 00:00 [received]
PHST- 2017/10/26 00:00 [revised]
PHST- 2017/11/03 00:00 [accepted]
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2017/11/09 06:00 [entrez]
AID - S1568-1637(17)30235-0 [pii]
AID - 10.1016/j.arr.2017.11.001 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2018 Jan;41:34-41. doi: 10.1016/j.arr.2017.11.001. Epub 2017 Nov 
      4.