PMID- 29114461
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2215-0013 (Print)
IS  - 2215-0013 (Electronic)
IS  - 2215-0013 (Linking)
VI  - 2
IP  - 4
DP  - 2015 Dec
TI  - The search for new biomarkers for cognition in schizophrenia.
PG  - 172-178
LID - 10.1016/j.scog.2015.10.004 [doi]
AB  - The search for biomarkers in cognition has been the focus of a large part of the 
      research on patients suffering from schizophrenia. The scientific literature is 
      heterogeneous, and few studies establishing an integrative model of pathogenesis 
      and therapeutic response are available in this field. In this review, we aimed to 
      summarize three essential aspects correlated with cognitive performance: 1) the 
      relationship between inflammation and cognition in schizophrenia, 2) the role of 
      prolactin in cognition, and 3) the association between cognition and neurotrophic 
      factors, particularly brain-derived neurotrophic factor (BDNF). Several studies 
      support the association of inflammatory markers with cognitive status in 
      schizophrenia. In recent decades, the development of effective therapies for 
      cognitive impairment in schizophrenia has focused on the search for 
      anti-inflammatory and immunomodulatory medications. Conversely, the implications 
      of prolactin and its functions in cognition, the transition to psychosis and the 
      diagnosis and prognosis of schizophrenia have been established independent of 
      antipsychotic treatment. With regard to neurotrophic factors, a recent study has 
      correlated BDNF levels with cognitive recovery in schizophrenic patients treated 
      with cognitive remediation. We conclude that although there is a diversity of 
      biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker 
      that has accumulated the vast majority of evidence in the current literature.
FAU - Penades, Rafael
AU  - Penades R
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Hospital Clinic Barcelona.
AD  - University of Barcelona.
AD  - Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS).
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
FAU - Garcia-Rizo, Clemente
AU  - Garcia-Rizo C
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Hospital Clinic Barcelona.
AD  - Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS).
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
FAU - Bioque, Miquel
AU  - Bioque M
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Hospital Clinic Barcelona.
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
FAU - Gonzalez-Rodriguez, Alexandre
AU  - Gonzalez-Rodriguez A
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Hospital Clinic Barcelona.
FAU - Cabrera, Bibiana
AU  - Cabrera B
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
FAU - Mezquida, Gisela
AU  - Mezquida G
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
FAU - Bernardo, Miquel
AU  - Bernardo M
AD  - Barcelona Clinic Schizophrenia Unit (BCSU).
AD  - Hospital Clinic Barcelona.
AD  - University of Barcelona.
AD  - Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS).
AD  - Centro de Investigacion en Red de Salud Mental (CIBERSAM).
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151217
PL  - United States
TA  - Schizophr Res Cogn
JT  - Schizophrenia research. Cognition
JID - 101632223
PMC - PMC5609637
OTO - NOTNLM
OT  - BDNF
OT  - Biomarkers
OT  - Cognition
OT  - Inflammation
OT  - Prolactin
OT  - Schizophrenia
EDAT- 2015/12/17 00:00
MHDA- 2015/12/17 00:01
PMCR- 2015/12/17
CRDT- 2017/11/09 06:00
PHST- 2017/11/09 06:00 [entrez]
PHST- 2015/12/17 00:00 [pubmed]
PHST- 2015/12/17 00:01 [medline]
PHST- 2015/12/17 00:00 [pmc-release]
AID - S2215-0013(15)00033-5 [pii]
AID - 10.1016/j.scog.2015.10.004 [doi]
PST - epublish
SO  - Schizophr Res Cogn. 2015 Dec 17;2(4):172-178. doi: 10.1016/j.scog.2015.10.004. 
      eCollection 2015 Dec.