PMID- 29114501
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 13
IP  - 4
DP  - 2017 Aug
TI  - Age-dependent differences of treadmill exercise on spatial learning ability 
      between young- and adult-age rats.
PG  - 381-386
LID - 10.12965/jer.1735070.535 [doi]
AB  - The effect of exercise, which increases hippocampal neurogenesis and improves 
      memory function, is well documented, however, differences in the effect of 
      exercise on young children and adults are not yet known. In the present study, 
      age-dependent differences of treadmill exercise on spatial learning ability 
      between young- and adult-age rats were investigated. The rats in the exercise 
      groups were forced to run on a motorized treadmill for 30 min once a day for 6 
      weeks. Radial 8-arm maze test was conducted for the determination of spatial 
      learning ability. Cell proliferation in the hippocampal dentate gyrus was 
      determined by 5-bromo-2'-deoxyuridine immunohistochemistry. Western blot for 
      brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) was 
      performed. In the present study, the number of errors in the young-age rats was 
      effectively decreased by treadmill exercise. Hippocampal neurogenesis was more 
      active in the young-age rats than in the adult-age rats. BDNF and TrkB expression 
      in the hippocampus was greater in the adult-age rats than in the young-age rats. 
      The results of this study showed that adults have excellent spatial learning 
      abilities than children, but the improvement of exercise-induced spatial learning 
      ability through neurogenesis is better in children.
FAU - Jin, Jun-Jang
AU  - Jin JJ
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
AD  - Department of Sports Medicine, College of Physical Education, Kyung Hee 
      University, Yongin, Korea.
FAU - Ko, Il-Gyu
AU  - Ko IG
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Sung-Eun
AU  - Kim SE
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Hwang, Lakkyong
AU  - Hwang L
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Lee, Man-Gyoon
AU  - Lee MG
AD  - Department of Sports Medicine, College of Physical Education, Kyung Hee 
      University, Yongin, Korea.
FAU - Kim, Dae-Young
AU  - Kim DY
AD  - Department of Sports Healthcare, College of Humanities & Social Sciences, Inje 
      University, Gimhae, Korea.
FAU - Jung, Sun-Young
AU  - Jung SY
AD  - Department of Physical Therapy, Hosan University, Gyeongsan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170829
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC5667613
OTO - NOTNLM
OT  - Age
OT  - Hippocampus
OT  - Neurogenesis
OT  - Spatial learning ability
OT  - Treadmill exercise
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2017/11/09 06:00
MHDA- 2017/11/09 06:01
PMCR- 2017/08/29
CRDT- 2017/11/09 06:00
PHST- 2017/07/17 00:00 [received]
PHST- 2017/08/05 00:00 [accepted]
PHST- 2017/11/09 06:00 [entrez]
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2017/11/09 06:01 [medline]
PHST- 2017/08/29 00:00 [pmc-release]
AID - jer-13-4-381 [pii]
AID - 10.12965/jer.1735070.535 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2017 Aug 29;13(4):381-386. doi: 10.12965/jer.1735070.535. 
      eCollection 2017 Aug.