PMID- 29115083
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20181113
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 32
IP  - 12
DP  - 2017 Dec
TI  - Clinical Evaluation of Techniques for Measuring Nasal-Specific Immunoglobulin E 
      in Pediatric Patients.
PG  - 2005-2008
LID - 10.3346/jkms.2017.32.12.2005 [doi]
AB  - Currently used methods for collecting nasal-specific immunoglobulin E (IgE) 
      require administration of a large amount of saline into the nostrils, which is 
      difficult in children. We designed two methods that are easy to use in children. 
      We measured nasal-specific IgE and evaluated clinical characteristics of 
      nasal-specific IgE in pediatric rhinitis. This study included 82 patients who 
      visited Kyungpook National University Children's Hospital from December 2014 to 
      July 2016 with rhinitis symptoms. Thirty patients used the spray method, and 52 
      patients used the swab method. We examined nasal-specific IgE to Dermatophagoides 
      farinae, Dermatophagoides pteronyssinus, Alternaria, birch, and weed mix. Thirty 
      patients had nasal-specific IgE concentrations of >/= 0.35 kIU/L. There was a 
      positive correlation between nasal-specific IgE and serum-specific IgE to D. 
      farinae and D. pteronyssinus (r = 0.548, P < 0.001; r = 0.656, P < 0.001). If we 
      regard positivity of skin prick test as standard, cutoff point of nasal-specific 
      IgE to D. farinae was 0.11 kIU/L and to D. pteronyssinus was 0.12 kIU/L. Based on 
      these cutoff points, five patients would be considered to have local allergic 
      rhinitis. The methods showed relatively high positivity for nasal-specific IgE, 
      which reflected the serum-specific IgE as well. These methods can be considered 
      to diagnose local allergic rhinitis in children.
CI  - (c) 2017 The Korean Academy of Medical Sciences.
FAU - Ahn, Ji Young
AU  - Ahn JY
AUID- ORCID: 0000-0003-2045-1629
AD  - Department of Pediatrics, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Hong, Suk Jin
AU  - Hong SJ
AUID- ORCID: 0000-0003-4844-5044
AD  - Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, 
      Korea.
FAU - Choi, Bong Seok
AU  - Choi BS
AUID- ORCID: 0000-0002-2129-7232
AD  - Department of Pediatrics, Kyungpook National University School of Medicine, 
      Daegu, Korea. bschoi@knu.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Alternaria/immunology
MH  - Animals
MH  - Child
MH  - Dermatophagoides farinae/immunology
MH  - Dermatophagoides pteronyssinus/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Nasal Cavity/metabolism
MH  - Plant Weeds/immunology
MH  - Rhinitis/*diagnosis/immunology/metabolism
MH  - Skin Tests
PMC - PMC5680500
OTO - NOTNLM
OT  - Child
OT  - Immunoglobulin E
OT  - Rhinitis
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2017/11/09 06:00
MHDA- 2018/06/19 06:00
PMCR- 2017/12/01
CRDT- 2017/11/09 06:00
PHST- 2017/06/16 00:00 [received]
PHST- 2017/08/27 00:00 [accepted]
PHST- 2017/11/09 06:00 [entrez]
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 32.2005 [pii]
AID - 10.3346/jkms.2017.32.12.2005 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2017 Dec;32(12):2005-2008. doi: 10.3346/jkms.2017.32.12.2005.