PMID- 29117321 OWN - NLM STAT- MEDLINE DCOM- 20180627 LR - 20240318 IS - 1460-2350 (Electronic) IS - 0268-1161 (Print) IS - 0268-1161 (Linking) VI - 32 IP - 9 DP - 2017 Sep 1 TI - The International Glossary on Infertility and Fertility Care, 2017. PG - 1786-1801 LID - 10.1093/humrep/dex234 [doi] AB - STUDY QUESTION: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individuals and couples experiencing fertility problems? SUMMARY ANSWER: A set of 283 consensus-based and evidence-driven terminologies used in infertility and fertility care has been generated through an inclusive consensus-based process with multiple stakeholders. WHAT IS KNOWN ALREADY: In 2006 the International Committee for Monitoring Assisted Reproductive Technologies (ICMART) published a first glossary of 53 terms and definitions. In 2009 ICMART together with WHO published a revised version expanded to 87 terms, which defined infertility as a disease of the reproductive system, and increased standardization of fertility treatment terminology. Since 2009, limitations were identified in several areas and enhancements were suggested for the glossary, especially concerning male factor, demography, epidemiology and public health issues. STUDY DESIGN, SIZE, DURATION: Twenty-five professionals, from all parts of the world and representing their expertise in a variety of sub-specialties, were organized into five working groups: clinical definitions; outcome measurements; embryology laboratory; clinical and laboratory andrology; and epidemiology and public health. Assessment for revisions, as well as expansion on topics not covered by the previous glossary, were undertaken. A larger group of independent experts and representatives from collaborating organizations further discussed and assisted in refining all terms and definitions. PARTICIPANTS/MATERIALS, SETTING, METHODS: Members of the working groups and glossary co-ordinators interacted through electronic mail and face-to-face in international/regional conferences. Two formal meetings were held in Geneva, Switzerland, with a final consensus meeting including independent experts as well as observers and representatives of international/regional scientific and patient organizations. MAIN RESULTS AND THE ROLE OF CHANCE: A consensus-based and evidence-driven set of 283 terminologies used in infertility and fertility care was generated to harmonize communication among health professionals and scientists as well as the lay public, patients and policy makers. Definitions such as 'fertility care' and 'fertility awareness' together with terminologies used in embryology and andrology have been introduced in the glossary for the first time. Furthermore, the definition of 'infertility' has been expanded in order to cover a wider spectrum of conditions affecting the capacity of individuals and couples to reproduce. The definition of infertility remains as a disease characterized by the failure to establish a clinical pregnancy; however, it also acknowledges that the failure to become pregnant does not always result from a disease, and therefore introduces the concept of an impairment of function which can lead to a disability. Additionally, subfertility is now redundant, being replaced by the term infertility so as to standardize the definition and avoid confusion. LIMITATIONS, REASONS FOR CAUTION: All stakeholders agreed to the vast majority of terminologies included in this glossary. In cases where disagreements were not resolved, the final decision was reached after a vote, defined before the meeting as consensus if passed with 75%. Over the following months, an external expert group, which included representatives from non-governmental organizations, reviewed and provided final feedback on the glossary. WIDER IMPLICATIONS OF THE FINDINGS: Some terminologies have different definitions, depending on the area of medicine, for example demographic or clinical as well as geographic differences. These differences were taken into account and this glossary represents a multinational effort to harmonize terminologies that should be used worldwide. STUDY FUNDING/COMPETING INTERESTS: None. TRIAL REGISTRATION NUMBER: N/A. CI - (c) The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com FAU - Zegers-Hochschild, Fernando AU - Zegers-Hochschild F AD - University Diego Portales, Program of Ethics and Public Policies in Human Reproduction; Clinica las Condes, Unit of Reproductive Medicine, Santiago, Chile. FAU - Adamson, G David AU - Adamson GD AD - ICMART, Palo Alto Medical Foundation Fertility Physicians of Northern California, Palo Alto, CA, USA. FAU - Dyer, Silke AU - Dyer S AD - Department of Obstetrics & Gynecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. FAU - Racowsky, Catherine AU - Racowsky C AD - Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - de Mouzon, Jacques AU - de Mouzon J AD - INSERM, EIM-ESHRE, ICMART, 15 rue Guilleminot, 75014 Paris, France. FAU - Sokol, Rebecca AU - Sokol R AD - Department of Medicine and Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA. FAU - Rienzi, Laura AU - Rienzi L AD - GENERA Center for Reproductive Medicine, Valle Giulia Clinic, 00197 Rome, Italy. FAU - Sunde, Arne AU - Sunde A AD - Department of Obstetrics and Gynecology, St. Olav's University Hospital, Trondheim, Norway. FAU - Schmidt, Lone AU - Schmidt L AD - Institute of Public Health, University of Copenhagen, Copenhagen, Denmark. FAU - Cooke, Ian D AU - Cooke ID AD - Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. FAU - Simpson, Joe Leigh AU - Simpson JL AD - March of Dimes Foundation, White Plains, NY, USA. FAU - van der Poel, Sheryl AU - van der Poel S AD - The Population Council, The Rockefeller University, New York, NY 10065, USA. LA - eng PT - Journal Article PL - England TA - Hum Reprod JT - Human reproduction (Oxford, England) JID - 8701199 SB - IM MH - Consensus MH - Female MH - *Fertility MH - Fertility Preservation/*standards MH - Humans MH - Infertility/*therapy MH - Male MH - Pregnancy MH - Reproductive Techniques, Assisted/*standards MH - *Terminology as Topic PMC - PMC5850297 OTO - NOTNLM OT - ART OT - fertility care OT - glossary OT - infertility OT - terminologies EDAT- 2017/11/09 06:00 MHDA- 2018/06/28 06:00 PMCR- 2017/07/28 CRDT- 2017/11/09 06:00 PHST- 2017/05/18 00:00 [received] PHST- 2017/06/05 00:00 [accepted] PHST- 2017/11/09 06:00 [entrez] PHST- 2017/11/09 06:00 [pubmed] PHST- 2018/06/28 06:00 [medline] PHST- 2017/07/28 00:00 [pmc-release] AID - 4049537 [pii] AID - dex234 [pii] AID - 10.1093/humrep/dex234 [doi] PST - ppublish SO - Hum Reprod. 2017 Sep 1;32(9):1786-1801. doi: 10.1093/humrep/dex234.