PMID- 29117612
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20181217
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 126
IP  - 8
DP  - 2018 Sep
TI  - Effect of Diabetes on the Assessment Role of 2-Oxoglutarate to the Severity of 
      Chronic Heart Failure.
PG  - 478-486
LID - 10.1055/s-0043-119076 [doi]
AB  - BACKGROUND: Serum 2-oxoglutarate can reflect the severity of chronic heart 
      failure (CHF) in patients without diabetes. Whether this predictive role persists 
      in type 2 diabetes mellitus (T2DM) patients is unclear. In this study, we 
      investigated this predictive role in T2DM patients and whether 2-oxoglutarate can 
      indicate the diastolic or systolic function of left ventricle. METHODS: One 
      hundred eighty CHF patients (76 with T2DM) and 66 healthy controls were studied. 
      2-Oxoglutarate was assayed by liquid chromatography-mass spectrometry/mass 
      spectrometry. Echocardiographic parameters, N-terminal pro-B-type natriuretic 
      peptide (NT-proBNP) and other parameters were measured. RESULTS: 2-Oxoglutarate 
      was increased in CHF patients with or without T2DM compared with controls (both 
      P<0.01). Patients with a lower left ventricular ejection fraction or a higher 
      NT-proBNP or left ventricular end-diastolic volume index had higher levels of 
      2-oxoglutarate (median, 18.77 mug/mL versus 11.25 mug/mL; median, 14.06 microg/ml 
      versus 9.39 microg/ml; median, 18.06 microg/mL versus 11.60 microg/mL, all P<0.05) in 
      nondiabetic patients but not in T2DM patients. In multiple logistic regression 
      analysis, NT-proBNP (OR=3.445, 95% CI=1.098 to 10.816, P=0.034) and left 
      ventricular end-diastolic diameter (OR=2.544, 95% CI=1.033 to 6.268, P=0.042) 
      were independently associated with increased 2-oxoglutarate in nondiabetic 
      patients. CONCLUSIONS: The levels of 2-oxoglutarate can reflect the clinical 
      severity of CHF in nondiabetic patients but not in those with T2DM, and it can be 
      used as a potential indicator of the systolic dysfunction of the left ventricle.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Chen, Pingan
AU  - Chen P
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Hou, Lina
AU  - Hou L
AD  - Department of Cardiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Luo, Yishan
AU  - Luo Y
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Chen, Lushan
AU  - Chen L
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Li, Shaonan
AU  - Li S
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Lei, Xiaoming
AU  - Lei X
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Huang, Jiankai
AU  - Huang J
AD  - Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Wu, Daihong
AU  - Wu D
AD  - Ultrasonic Department, Guangzhou First People's Hospital, Guangzhou Medical 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20171108
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Ketoglutaric Acids)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*blood/*diagnosis/epidemiology/physiopathology
MH  - Humans
MH  - Ketoglutaric Acids/*blood
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2017/11/09 06:00
MHDA- 2018/12/18 06:00
CRDT- 2017/11/09 06:00
PHST- 2017/11/09 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2017/11/09 06:00 [entrez]
AID - 10.1055/s-0043-119076 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2018 Sep;126(8):478-486. doi: 
      10.1055/s-0043-119076. Epub 2017 Nov 8.