PMID- 29118519
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 0974-7753 (Print)
IS  - 0974-9241 (Electronic)
IS  - 0974-7753 (Linking)
VI  - 9
IP  - 4
DP  - 2017 Oct-Dec
TI  - Detection of Tumor Necrosis Factor-alpha in Nonlesional Tissues of Alopecia 
      Areata Patients: A Prove for a Systemic Disease.
PG  - 154-159
LID - 10.4103/ijt.ijt_47_17 [doi]
AB  - INTRODUCTION: The pathogenesis of alopecia areata (AA) remains incompletely 
      understood. Different cytokines may play a role in AA. Tumor necrosis 
      factor-alpha (TNF-alpha) has been shown to be inhibitory to hair follicle growth in 
      in vitro studies suggesting that it may play an important role in AA. This study 
      was conducted to assess the presence of TNF-alpha in lesional and nonlesional skin of 
      AA, to review its possible role in AA, and to show whether AA is a systemic or 
      localized disease by comparing the level of TNF-alpha between lesional and 
      nonlesional skin biopsies of the patients. MATERIALS AND METHODS: Thirty patients 
      with AA and thirty age- and sex-matched healthy controls were included in the 
      study. A 4 mm punch skin biopsy was taken from lesional and nonlesional skin of 
      every patient, as well as from the normal skin of each individual in the control 
      group for immunohistochemical analysis of TNF-alpha. RESULTS: The level of TNF-alpha in 
      lesional skin biopsies was significantly higher than in nonlesional skin biopsies 
      of patients as well as controls' biopsies. Furthermore, TNF-alpha level in 
      nonlesional biopsies of patients was significantly higher than the level in 
      controls' biopsies. CONCLUSIONS: We concluded that skin of AA has a high level of 
      TNF-alpha (a normal inhibitor of hair follicle growth in vitro). This high level may 
      point to the important role of TNF-alpha in AA. Further studies should be conducted 
      to detect the level of TNF-alpha in long-standing AA and the more severe cases of AA.
FAU - Gohary, Yasser Mostsfa
AU  - Gohary YM
AD  - Department of Dermatology, Faculty of Medicine, Beni-Suef University, Beni Suef, 
      Egypt.
FAU - Abdel Fattah, Dina Sabry
AU  - Abdel Fattah DS
AD  - Department of Biochemistry, Faculty of Medicine, Beni-Suef University, Beni Suef, 
      Egypt.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Trichology
JT  - International journal of trichology
JID - 101534370
PMC - PMC5655623
OTO - NOTNLM
OT  - Alopecia areata
OT  - lesional
OT  - nonlesional
OT  - tumor necrosis factor-alpha
COIS- There are no conflicts of interest.
EDAT- 2017/11/10 06:00
MHDA- 2017/11/10 06:01
PMCR- 2017/10/01
CRDT- 2017/11/10 06:00
PHST- 2017/11/10 06:00 [entrez]
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2017/11/10 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - IJT-9-154 [pii]
AID - 10.4103/ijt.ijt_47_17 [doi]
PST - ppublish
SO  - Int J Trichology. 2017 Oct-Dec;9(4):154-159. doi: 10.4103/ijt.ijt_47_17.