PMID- 29118808 OWN - NLM STAT- MEDLINE DCOM- 20180703 LR - 20191210 IS - 1687-5273 (Electronic) IS - 1687-5265 (Print) VI - 2017 DP - 2017 TI - Pathological Brain Detection Using Weiner Filtering, 2D-Discrete Wavelet Transform, Probabilistic PCA, and Random Subspace Ensemble Classifier. PG - 4205141 LID - 10.1155/2017/4205141 [doi] LID - 4205141 AB - Accurate diagnosis of pathological brain images is important for patient care, particularly in the early phase of the disease. Although numerous studies have used machine-learning techniques for the computer-aided diagnosis (CAD) of pathological brain, previous methods encountered challenges in terms of the diagnostic efficiency owing to deficiencies in the choice of proper filtering techniques, neuroimaging biomarkers, and limited learning models. Magnetic resonance imaging (MRI) is capable of providing enhanced information regarding the soft tissues, and therefore MR images are included in the proposed approach. In this study, we propose a new model that includes Wiener filtering for noise reduction, 2D-discrete wavelet transform (2D-DWT) for feature extraction, probabilistic principal component analysis (PPCA) for dimensionality reduction, and a random subspace ensemble (RSE) classifier along with the K-nearest neighbors (KNN) algorithm as a base classifier to classify brain images as pathological or normal ones. The proposed methods provide a significant improvement in classification results when compared to other studies. Based on 5 x 5 cross-validation (CV), the proposed method outperforms 21 state-of-the-art algorithms in terms of classification accuracy, sensitivity, and specificity for all four datasets used in the study. FAU - Jha, Debesh AU - Jha D AUID- ORCID: 0000-0002-8078-6730 AD - Department of Information and Communication Engineering, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju 61452, Republic of Korea. FAU - Kim, Ji-In AU - Kim JI AD - Department of Information and Communication Engineering, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju 61452, Republic of Korea. FAU - Choi, Moo-Rak AU - Choi MR AD - School of Electrical Engineering, Korea University, 145 Anam-ro, Sungbuk-gu, Seoul 02841, Republic of Korea. FAU - Kwon, Goo-Rak AU - Kwon GR AUID- ORCID: 0000-0003-3486-8812 AD - Department of Information and Communication Engineering, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju 61452, Republic of Korea. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20171003 PL - United States TA - Comput Intell Neurosci JT - Computational intelligence and neuroscience JID - 101279357 SB - IM MH - Algorithms MH - Artifacts MH - Brain/*diagnostic imaging/pathology MH - Brain Diseases/*diagnostic imaging/pathology MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - *Magnetic Resonance Imaging/methods MH - Neuroimaging/methods MH - *Principal Component Analysis MH - Probability MH - Sensitivity and Specificity MH - *Wavelet Analysis PMC - PMC5651159 EDAT- 2017/11/10 06:00 MHDA- 2018/07/04 06:00 PMCR- 2017/10/03 CRDT- 2017/11/10 06:00 PHST- 2017/05/10 00:00 [received] PHST- 2017/08/07 00:00 [revised] PHST- 2017/08/23 00:00 [accepted] PHST- 2017/11/10 06:00 [entrez] PHST- 2017/11/10 06:00 [pubmed] PHST- 2018/07/04 06:00 [medline] PHST- 2017/10/03 00:00 [pmc-release] AID - 10.1155/2017/4205141 [doi] PST - ppublish SO - Comput Intell Neurosci. 2017;2017:4205141. doi: 10.1155/2017/4205141. Epub 2017 Oct 3.