PMID- 29118918
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 9
IP  - 10
DP  - 2017
TI  - Image-guided dendritic cell-based vaccine immunotherapy in murine carcinoma 
      models.
PG  - 4564-4573
AB  - In recent decades, immunotherapy has undergone extensive developments for 
      oncologic therapy applications. Dendritic cells (DCs) plays a fundamental role in 
      cell-based vaccination immunotherapy against various types of cancer. It involves 
      stimulating innate and adaptive immunity, in particular cytotoxic T-cell mediated 
      antitumor effects, against targeted tumors and has been studied in both 
      preclinical and clinical settings. Nevertheless, clinical outcomes have been 
      unsatisfying. The antitumor response requires sufficient migration of viable DCs 
      from primary administration site to targeted tumors through related lymphatics. 
      The dynamics and mechanisms of the DCs migration still need further 
      investigation. Here, we briefly introduce the current clinically applicable 
      methods for manufacturing DC-based cancer vaccines and their most commonly used 
      non-invasive, real-time tracking approaches. Furthermore, we propose a hypothesis 
      that intraperitoneal injection may improve the efficiency of DC-based cancer 
      vaccine.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangdong Provincial Engineering Technology Research Center of Minimally Invasive 
      SurgeryGuangzhou, China.
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Sun, Chong
AU  - Sun C
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Wang, Sijia
AU  - Wang S
AD  - Department of Dermatology, Nanfang Hospital, Southern Medical 
      UniversityGuangzhou, Guangdong, China.
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Shang, Na
AU  - Shang N
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Figini, Matteo
AU  - Figini M
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Ma, Quanhong
AU  - Ma Q
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Gu, Shanzhi
AU  - Gu S
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
AD  - Department of Interventional Radiology, Hunan Cancer Hospital, Xiangya School of 
      Medicine, Central South UniversityHunan, China.
FAU - Procissi, Daniele
AU  - Procissi D
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Yaghmai, Vahid
AU  - Yaghmai V
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
AD  - Robert H. Lurie Comprehensive Cancer CenterChicago, IL, USA.
FAU - Li, Guoxin
AU  - Li G
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangdong Provincial Engineering Technology Research Center of Minimally Invasive 
      SurgeryGuangzhou, China.
FAU - Larson, Andrew
AU  - Larson A
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
AD  - Robert H. Lurie Comprehensive Cancer CenterChicago, IL, USA.
FAU - Zhang, Zhuoli
AU  - Zhang Z
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
AD  - Robert H. Lurie Comprehensive Cancer CenterChicago, IL, USA.
LA  - eng
GR  - R01 CA196967/CA/NCI NIH HHS/United States
GR  - R01 CA209886/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171015
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC5666065
OTO - NOTNLM
OT  - Dendritic cells
OT  - animal models
OT  - cancer vaccine
OT  - image techniques
COIS- None.
EDAT- 2017/11/10 06:00
MHDA- 2017/11/10 06:01
PMCR- 2017/10/15
CRDT- 2017/11/10 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/11/10 06:00 [entrez]
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2017/11/10 06:01 [medline]
PHST- 2017/10/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2017 Oct 15;9(10):4564-4573. eCollection 2017.