PMID- 29119057
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 7
IP  - 10
DP  - 2017
TI  - Dendritic cells based immunotherapy.
PG  - 2091-2102
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells, and tumor 
      antigen-loaded DCs (DC-vaccines) can activate tumor-specific cytotoxic T 
      lymphocytes (CTLs) in lymphatic tissues. DC vaccination is a newly emerging and 
      potent form of cancer immunotherapy and has clinically relevant mechanisms of 
      action with great potential for the systemic treatment of cancers. However, 
      clinical trials have demonstrated relatively poor therapeutic efficacy. The 
      efficacy of DC-vaccines is strongly influenced by various techniques for the 
      priming antigen loading onto DCs and their ability to migrate to the draining 
      lymph nodes (LNs). Therefore, it is critical to improve DC-vaccines homing to 
      draining LNs after administration in order to optimize DC-based therapy for 
      individual patients. This review underlines 1) appropriate strategy to load tumor 
      antigens onto DCs and 2) to optimize vaccine administration methods to ensure 
      loaded DCs can migrate to LNs, in particular, Intraperitoneal (IP) injection. IP 
      injection of DC-based vaccine may be a potential regimen for gastrointestinal 
      tumors including hepatocellular carcinoma (HCC) and pancreatic adenocarcinoma 
      (PDAC) since huge populations of LNs are present throughout the gastrointestinal 
      track. Which might improve the subsequent migration to LNs.
FAU - Shang, Na
AU  - Shang N
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Figini, Matteo
AU  - Figini M
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Shangguan, Junjie
AU  - Shangguan J
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Sun, Chong
AU  - Sun C
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Pan, Liang
AU  - Pan L
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Ma, Quanhong
AU  - Ma Q
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
FAU - Zhang, Zhuoli
AU  - Zhang Z
AD  - Department of Radiology, Feinberg School of Medicine, Northwestern 
      UniversityChicago, IL, USA.
AD  - Robert H. Lurie Comprehensive Cancer CenterChicago, IL, USA.
LA  - eng
GR  - R01 CA196967/CA/NCI NIH HHS/United States
GR  - R01 CA209886/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171001
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC5665855
OTO - NOTNLM
OT  - Dendritic cells
OT  - cancer vaccine
OT  - hepatocellular carcinoma
OT  - immunotherapy
OT  - pancreatic cancer
COIS- None.
EDAT- 2017/11/10 06:00
MHDA- 2017/11/10 06:01
PMCR- 2017/10/01
CRDT- 2017/11/10 06:00
PHST- 2017/09/06 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/11/10 06:00 [entrez]
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2017/11/10 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2017 Oct 1;7(10):2091-2102. eCollection 2017.