PMID- 29119369
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181113
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Linking)
VI  - 9
IP  - 4
DP  - 2018 Aug
TI  - Clinical Importance of Temporal Bone Features for the Efficacy of 
      Contrast-Enhanced Sonothrombolysis: a Retrospective Analysis of the NOR-SASS 
      Trial.
PG  - 333-339
LID - 10.1007/s12975-017-0583-x [doi]
AB  - Contrast-enhanced sonothrombolysis (CEST) seems to be a safe and promising 
      treatment in acute ischemic stroke. It remains unknown if temporal bone features 
      may influence the efficacy of CEST. We investigated the association between 
      different temporal bone features on admission computed tomography (CT) scan and 
      the outcome in acute ischemic stroke patients included in the randomized 
      Norwegian Sonothrombolysis in Acute Stroke Study (NOR-SASS). Patients diagnosed 
      as stroke mimics and those with infratentorial stroke or with incorrect 
      insonation were excluded. We retrospectively assessed temporal bone heterogeneity 
      (presence of diploe), diploe ratio, thickness, and density on admission CT scans. 
      National institute of Health Stroke Scale (NIHSS) at 24 h and modified Rankin 
      Scale (mRS) at 3 months were correlated with CT findings both in CEST and sham 
      CEST patients. A total of 99 patients were included of which 52 were assigned to 
      CEST and 47 to sham CEST. Approximately 20% patients had a heterogeneous temporal 
      bone in both the CEST and sham CEST group. All temporal bone CT features studied 
      were associated with female sex. In the CEST group, temporal bone heterogeneity 
      (p = 0.006) and higher temporal bone diploe ratio (p = 0.002) were associated 
      with higher NIHSS at 24 h. There was no association between temporal bone 
      features and mRS at 3 months. Approximately 20% of acute ischemic stroke patients 
      have heterogeneous temporal bone and may be resistant to standard 2-MHz 
      transcranial Doppler ultrasound treatment. Sonothrombolysis resistance may easily 
      be predicted by admission CT for better selection.
FAU - Novotny, Vojtech
AU  - Novotny V
AUID- ORCID: 0000-0002-9137-3894
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway. vojtech.novotny@helse-bergen.no.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway. 
      vojtech.novotny@helse-bergen.no.
FAU - Nacu, Aliona
AU  - Nacu A
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Kvistad, Christopher E
AU  - Kvistad CE
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Fromm, Annette
AU  - Fromm A
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Neckelmann, Gesche F
AU  - Neckelmann GF
AD  - Department of Radiology, Haukeland University Hospital, Bergen, Norway.
FAU - Khanevski, Andrej N
AU  - Khanevski AN
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - The National Association for Public Health, Oslo, Norway.
FAU - Tobro, Haakon
AU  - Tobro H
AD  - Department of Neurology, Telemark Central Hospital, Skien, Norway.
FAU - Waje-Andreassen, Ulrike
AU  - Waje-Andreassen U
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
FAU - Naess, Halvor
AU  - Naess H
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, 
      Norway.
FAU - Thomassen, Lars
AU  - Thomassen L
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Logallo, Nicola
AU  - Logallo N
AD  - Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, 
      N-5021, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
AD  - Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171108
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Ischemia/complications
MH  - Contrast Media/metabolism
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Retrospective Studies
MH  - Stroke/*diagnostic imaging/etiology/*therapy
MH  - Temporal Bone/*diagnostic imaging
MH  - Thrombolytic Therapy/*methods
MH  - Tomography Scanners, X-Ray Computed
MH  - Ultrasonography, Doppler, Transcranial
OTO - NOTNLM
OT  - CT scan
OT  - Cerebral infarction
OT  - Sonothrombolysis
OT  - Temporal bone
OT  - Thrombolysis
OT  - Ultrasound
EDAT- 2017/11/10 06:00
MHDA- 2018/11/10 06:00
CRDT- 2017/11/10 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/10/26 00:00 [revised]
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2017/11/10 06:00 [entrez]
AID - 10.1007/s12975-017-0583-x [pii]
AID - 10.1007/s12975-017-0583-x [doi]
PST - ppublish
SO  - Transl Stroke Res. 2018 Aug;9(4):333-339. doi: 10.1007/s12975-017-0583-x. Epub 
      2017 Nov 8.