PMID- 29120844
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20190129
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 259
DP  - 2018 Jan
TI  - Prevalence and clinical-demographic correlates of hyperhomocysteinemia in 
      inpatients with bipolar disorder in a Han Chinese population.
PG  - 364-369
LID - S0165-1781(16)31117-9 [pii]
LID - 10.1016/j.psychres.2017.08.063 [doi]
AB  - Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent 
      in patients with bipolar disorder (BD), placing them at greater risk of 
      cardiovascular disease and possibly serving as a disease biomarker. However, the 
      correlation of HHcy with demographic or clinical parameters is not well known. In 
      this study, we examined the prevalence of HHcy and its association with these 
      parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) 
      levels were determined in 198 BD inpatients and 84 healthy controls. HHcy was 
      defined when Hcy concentration exceeded 15.0micromol/L. Affective symptomatology was 
      assessed by the Young Mania Rating Scale, Hamilton Depression Rating Scale and 
      the Clinical Global Impressions severity scale. Compared to healthy controls, BD 
      patients had a significantly higher prevalence (34.85% vs. 19.05%) of HHcy and a 
      higher absolute level of homocysteine. Logistic regression analysis demonstrated 
      that BD patients with HHcy were more likely to be male, have elevated BMI, more 
      frequent treatment on lithium but less on valproate. These results suggest that 
      Chinese inpatients with bipolar disorder have a higher rate of HHcy than the 
      general population, and those at greatest risk are male, have an elevated BMI, 
      and take more lithium but less valproate therapy.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Zhou, Shuang-Jiang
AU  - Zhou SJ
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Zhang, Li-Gang
AU  - Zhang LG
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Chen, Hong-Mei
AU  - Chen HM
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Li, Ju-Yan
AU  - Li JY
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Li, Ran
AU  - Li R
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Zhang, Xi-Mei
AU  - Zhang XM
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Wang, Ning
AU  - Wang N
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Cassidy, Ryan M
AU  - Cassidy RM
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Zheng, Yingjun
AU  - Zheng Y
AD  - The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai 
      Hospital, Guangzhou, China.
FAU - Ning, Yuping
AU  - Ning Y
AD  - The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai 
      Hospital, Guangzhou, China.
FAU - Wang, Shao-Li
AU  - Wang SL
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. 
      Electronic address: wangshl82@sina.com.
FAU - Chen, Jing-Xu
AU  - Chen JX
AD  - Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. 
      Electronic address: chenjx1110@163.com.
FAU - Zhang, Xiang-Yang
AU  - Zhang XY
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA; The Affiliated Brain Hospital of 
      Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, China. 
      Electronic address: Xiang.y.zhang@uth.tmc.edu.
LA  - eng
GR  - TL1 TR000369/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20170824
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/blood/*complications/ethnology
MH  - China/epidemiology
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/epidemiology/*psychology
MH  - Inpatients/*psychology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Body mass index
OT  - Homocysteine
OT  - Lithium
OT  - Prevalence
OT  - Valproate
EDAT- 2017/11/10 06:00
MHDA- 2018/10/31 06:00
CRDT- 2017/11/10 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2017/05/29 00:00 [revised]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
PHST- 2017/11/10 06:00 [entrez]
AID - S0165-1781(16)31117-9 [pii]
AID - 10.1016/j.psychres.2017.08.063 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Jan;259:364-369. doi: 10.1016/j.psychres.2017.08.063. Epub 
      2017 Aug 24.