PMID- 29120944
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20190731
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 128
IP  - 3
DP  - 2018 Mar
TI  - Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic 
      Factor Gene for Chronic Postsurgical Pain.
PG  - 587-597
LID - 10.1097/ALN.0000000000001977 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the association between 
      single-nucleotide polymorphisms and chronic postsurgical pain. METHODS: Using 
      GoldenGate genotyping assays, we genotyped 638 polymorphisms within 54 
      pain-related genes in 1,152 surgical patients who were enrolled in our Persistent 
      Pain after Surgery Study. Patients were contacted by phone to determine whether 
      they had chronic postsurgical pain at 12 months. Polymorphisms identified were 
      validated in a matched cohort of 103 patients with chronic postsurgical pain and 
      103 patients who were pain free. The functions of targeted polymorphisms were 
      tested in an experimental plantar incisional nociception model using knock-in 
      mice. RESULTS: At 12 months after surgery, 246 (21.4%) patients reported chronic 
      postsurgical pain. Forty-two polymorphisms were found to be associated with 
      chronic postsurgical pain, 19 decreased the risk of pain, and 23 increased the 
      risk of pain. Patients carrying allele A of rs6265 polymorphism in brain-derived 
      neurotrophic factor (BDNF) had a lower risk of chronic postsurgical pain in the 
      discovery and validation cohorts, with an adjusted odds ratio (95% CI) of 0.62 
      (0.43 to 0.90) and 0.57 (0.39 to 0.85), respectively. Age less than 65 yr, male 
      sex, and prior history of pain syndrome were associated with an increased risk of 
      pain. Genetic polymorphisms had higher population attributable risk (7.36 to 
      11.7%) compared with clinical risk factors (2.90 to 5.93%). Importantly, rs6265 
      is a substitution of valine by methionine at amino acid residue 66 (Val66Met) and 
      was associated with less mechanical allodynia in BDNF mice compared with BDNF 
      group after plantar incision. CONCLUSIONS: This study demonstrated that genetic 
      variant of BDNF rs6265G>A is associated with decreased risk of chronic 
      postsurgical pain.
FAU - Tian, Yuanyuan
AU  - Tian Y
AD  - From the Department of Anaesthesia and Intensive Care (Y.T., X.L., Z.M., S.K., 
      I.H.T.H., B.J., S.T., T.G., W.K.K.W., M.T.V.C.), Li Ka Shing Institute of Health 
      Sciences (Y.T., X.L., S.K., I.H.T.H., B.J., S.T., S.H.W., J.Y., W.K.K.W., 
      M.T.V.C.), School of Biomedical Sciences (Y.S., C.H.K.C.), and Department of 
      Medicine and Therapeutics (S.H.W., J.Y., W.K.K.W.), Institute of Digestive 
      Disease, State Key Laboratory of Digestive Disease, Chinese University of Hong 
      Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China; 
      the Shandong Provincial Key Laboratory of Mental Disorders, Department of 
      Neurobiology, School of Medicine, Shandong University, Jinan, Shandong, China 
      (M.J., H.Y., Z.C.); the Institute of Human Genetics, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany (P.L); and the Department of Anaesthesia and Intensive Care, 
      Tuen Mun Hospital, Hong Kong Special Administrative Region, China (B.C.P.C., 
      C.K.M.L.).
FAU - Liu, Xiaodong
AU  - Liu X
FAU - Jia, Mingzhong
AU  - Jia M
FAU - Yu, Hui
AU  - Yu H
FAU - Lichtner, Peter
AU  - Lichtner P
FAU - Shi, Yujian
AU  - Shi Y
FAU - Meng, Zhaoyu
AU  - Meng Z
FAU - Kou, Shanglong
AU  - Kou S
FAU - Ho, Idy H T
AU  - Ho IHT
FAU - Jia, Bo
AU  - Jia B
FAU - Cheng, Benny C P
AU  - Cheng BCP
FAU - Lam, Carmen K M
AU  - Lam CKM
FAU - Tsang, Sharon
AU  - Tsang S
FAU - Wong, Sunny H
AU  - Wong SH
FAU - Yu, Jun
AU  - Yu J
FAU - Cheng, Christopher H K
AU  - Cheng CHK
FAU - Gin, Tony
AU  - Gin T
FAU - Wu, William K K
AU  - Wu WKK
FAU - Chen, Zheyu
AU  - Chen Z
FAU - Chan, Matthew T V
AU  - Chan MTV
CN  - Persistent Pain after Surgery Study Investigators
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
RN  - 0 (Brain-Derived Neurotrophic Factor)
EIN - Anesthesiology. 2018 May;128(5):1049. PMID: 29537980
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chronic Pain/*genetics
MH  - Cohort Studies
MH  - Disease Models, Animal
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *Genotyping Techniques
MH  - Humans
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Pain, Postoperative/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2017/11/10 06:00
MHDA- 2019/07/30 06:00
CRDT- 2017/11/10 06:00
PHST- 2017/11/10 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2017/11/10 06:00 [entrez]
AID - 10.1097/ALN.0000000000001977 [doi]
PST - ppublish
SO  - Anesthesiology. 2018 Mar;128(3):587-597. doi: 10.1097/ALN.0000000000001977.