PMID- 29121758 OWN - NLM STAT- MEDLINE DCOM- 20180627 LR - 20180627 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 249 DP - 2017 Dec 15 TI - Tpeak-Tend dispersion as a predictor for malignant arrhythmia events in patients with vasospastic angina. PG - 61-65 LID - S0167-5273(17)31928-9 [pii] LID - 10.1016/j.ijcard.2017.07.093 [doi] AB - BACKGROUND: Tpeak-Tend interval (Tp-e interval) in electrocardiogram (ECG) has been reported to predict malignant arrhythmia events (MAE) in ST-segment elevation myocardial infarction and ion channelopathy. Tp-e interval and other ECG parameters as predictors for MAE was evaluated in patients with vasospastic angina (VA). METHODS AND RESULTS: Sixty-two patients with VA (Non-MAE group) and 20 patients with VA complicated by MAE (MAE group) were enrolled in our Division of Cardiology between January 2010 and December 2015. Continuous variables were analyzed by t-test and categorical variables by Chi-square analysis. Patients with MAE showed greater QTc (corrected QT interval) dispersion (P=0.005), Tp-ec (corrected Tp-e) interval (P=0.001), Tp-ec dispersion (P<0.001) and Tp-e/QT ratio (P<0.001) than those in non-MAE groups when ST-segment elevated. After elevated ST-segment returned, there were no significant differences in these ECG parameters between two groups (All P>0.05). At univariate binary logistic regression analysis QTc dispersion (odds ratio(OR)=1.133; P=0.013), Tp-ec (OR=1.058; P=0.003), Tp-e/QT (OR=1.403; P=0.001), and Tp-ec dispersion (OR=1.497; P=0.004) were significantly associated with MAE. At multivariable logistic regression analysis, Tp-ec dispersion remained a predictor of MAE. Receiver operating characteristic (ROC) curve analysis showed that only AUC (Area under curve) of Tp-ec dispersion had significant difference with those in QTc dispersion (P<0.001), Tp-ec (P=0.003), and Tp-e/QT ratio (P=0.012), respectively. CONCLUSIONS: QTc dispersion, Tp-ec, Tp-e/QT and Tp-ec dispersion were significantly increased in VA patients with MAE than those without MAE when coronary spasm was onset. Prolonged Tp-ec dispersion was the best discriminators and a strong independent predictor of MAE in VA patients. CI - Copyright (c) 2017. Published by Elsevier B.V. FAU - Xianpei, Wang AU - Xianpei W AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. FAU - Sha, Wu AU - Sha W AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. FAU - Chuanyu, Gao AU - Chuanyu G AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. Electronic address: gaocy1104@163.com. FAU - Juanjuan, Yan AU - Juanjuan Y AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. Electronic address: 781544051@qq.com. FAU - Chong, Chen AU - Chong C AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. Electronic address: 173133621@qq.com. FAU - Yongen, Shi AU - Yongen S AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. FAU - Yu, Feng AU - Yu F AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. Electronic address: 1842247069@qq.com. FAU - Zhenhao, Lin AU - Zhenhao L AD - Department of Cardiology, People's Hospital of Zhengzhou University, Institute of Cardiovascular Epidemiology of Henan Province, Zhengzhou, Henan Province, China. Electronic address: 1114158582@qq.com. LA - eng PT - Journal Article PT - Observational Study PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM CIN - Int J Cardiol. 2017 Dec 15;249:75-76. PMID: 29121761 MH - Adult MH - Aged MH - Angina Pectoris/diagnosis/epidemiology/*physiopathology MH - Arrhythmias, Cardiac/diagnosis/epidemiology/*physiopathology MH - Coronary Vasospasm/diagnosis/epidemiology/*physiopathology MH - Electrocardiography/*methods MH - Female MH - Humans MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - ST Elevation Myocardial Infarction/diagnosis/epidemiology/*physiopathology OTO - NOTNLM OT - Malignant arrhythmia events OT - Tp-e dispersion OT - Tp-e interval OT - Vasospastic angina EDAT- 2017/11/11 06:00 MHDA- 2018/06/28 06:00 CRDT- 2017/11/11 06:00 PHST- 2017/03/27 00:00 [received] PHST- 2017/07/02 00:00 [revised] PHST- 2017/07/24 00:00 [accepted] PHST- 2017/11/11 06:00 [entrez] PHST- 2017/11/11 06:00 [pubmed] PHST- 2018/06/28 06:00 [medline] AID - S0167-5273(17)31928-9 [pii] AID - 10.1016/j.ijcard.2017.07.093 [doi] PST - ppublish SO - Int J Cardiol. 2017 Dec 15;249:61-65. doi: 10.1016/j.ijcard.2017.07.093.