PMID- 29122355
OWN - NLM
STAT- MEDLINE
DCOM- 20180823
LR  - 20181202
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 618
DP  - 2018 Mar 15
TI  - Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls 
      (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study.
PG  - 674-681
LID - S0048-9697(17)31949-6 [pii]
LID - 10.1016/j.scitotenv.2017.07.232 [doi]
AB  - Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated 
      biphenyls (PCBs) have been a persistent and significant environmental health 
      issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) 
      has been identified as a major route of exposure among developing fetuses and 
      newborn infants. Among Children's Health and Environmental Health of Korea 
      (CHECK) cohort population, pregnant females (n=148) and their matching newborn 
      infants (n=117) recruited from four cities of Korea in 2011 were investigated. 
      The blood serum and cord blood serum were sampled at delivery, and measured for 
      19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic 
      characteristics, and dietary habits were conducted. The most frequently detected 
      POPs in both maternal blood and cord blood were p,p'-dichlorodiphenyl 
      dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) 
      and PCB153 (95% in maternal, 74% in cord blood serum). The levels of 
      dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5ng/g lw) 
      and cord blood serum (average 77.5ng/g lw) were comparable to or greater than 
      those reported in Japan about a decade ago. Approximately two thirds of the 
      pregnant women and newborn infants showed the p,p'-DDE concentrations exceeding 
      the biological equivalent (BE) corresponding to 10(-6) excess cancer risk. In 
      addition, less chlorinated PCBs were detected higher in both maternal and cord 
      serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy 
      consumption among the subjects was positively associated, and tea consumption was 
      negatively associated with serum levels of several POPs. Our results show that 
      the exposure to legacy POPs, especially DDTs, among pregnant women and newborn 
      infants is still prevailing, thus warrants measures for exposure mitigation among 
      these vulnerable populations.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Choi, Sooran
AU  - Choi S
AD  - College of Medicine, Inha University, Incheon 22332, Republic of Korea.
FAU - Kim, Hai-Joong
AU  - Kim HJ
AD  - College of Medicine, Korea University, Ansan 15355, Republic of Korea.
FAU - Kim, Sunmi
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  - College of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea.
FAU - Kim, Sungjoo
AU  - Kim S
AD  - College of Medicine, Hallym University, Seoul 07226, Republic of Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - College of Natural Sciences, Soonchunhyang University, Asan 31538, Republic of 
      Korea.
FAU - Shim, Soon-Sup
AU  - Shim SS
AD  - College of Medicine, Jeju National University, Jeju 63241, Republic of Korea.
FAU - Lee, Inae
AU  - Lee I
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - College of Science and Technology, Hanyang University, Ansan 15355, Republic of 
      Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Lee, Jeong Jae
AU  - Lee JJ
AD  - College of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea. 
      Electronic address: jjlee@schmc.ac.kr.
FAU - Kim, Su Young
AU  - Kim SY
AD  - College of Medicine, Jeju National University, Jeju 63241, Republic of Korea. 
      Electronic address: suy0202@jejunu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20171106
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Cities
MH  - Cohort Studies
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Mothers
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Pregnancy
MH  - Republic of Korea
MH  - Young Adult
OTO - NOTNLM
OT  - Maternal blood
OT  - Organochlorine pesticides (OCPs)
OT  - Polychlorinated biphenyls (PCBs)
OT  - Umbilical cord blood
EDAT- 2017/11/11 06:00
MHDA- 2018/08/24 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/07/11 00:00 [revised]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/08/24 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - S0048-9697(17)31949-6 [pii]
AID - 10.1016/j.scitotenv.2017.07.232 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 Mar 15;618:674-681. doi: 10.1016/j.scitotenv.2017.07.232. 
      Epub 2017 Nov 6.