PMID- 29122705
OWN - NLM
STAT- MEDLINE
DCOM- 20180719
LR  - 20181019
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 86
DP  - 2018 Jan
TI  - Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: 
      Regulation by BDNF.
PG  - 41-49
LID - S1044-7431(17)30245-2 [pii]
LID - 10.1016/j.mcn.2017.11.003 [doi]
AB  - Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase 
      (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose 
      expression changes during postnatal development and aging. Here, we studied STEP 
      ontogeny in mouse brain and changes in STEP with age with emphasis on the 
      possible regulation by BDNF. We found that STEP expression increased during the 
      first weeks of life, reaching adult levels by 2-3weeks of age in the striatum and 
      cortex, and by postnatal day (P) 7 in the hippocampus. STEP protein levels were 
      unaffected in BDNF(+/-) mice, but were significantly reduced in the striatum and 
      cortex, but not in the hippocampus, of BDNF(-/-) mice at P7 and P14. In adult 
      wild-type mice there were no changes in cortical and hippocampal STEP(61) levels 
      with age. Conversely, striatal STEP levels were reduced from 12months of age, 
      correlating with higher ubiquitination and increased BDNF content and signaling. 
      Lower STEP levels in older mice were paralleled by increased phosphorylation of 
      its substrates. Since altered STEP levels are involved in cellular malfunctioning 
      events, its reduction in the striatum with increasing age should encourage future 
      studies of how this imbalance might participate in the aging process.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Cases, Silvia
AU  - Cases S
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia.
FAU - Saavedra, Ana
AU  - Saavedra A
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia; Institut d'Investigacions 
      Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de 
      Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 
      Spain.
FAU - Tyebji, Shiraz
AU  - Tyebji S
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia; Institut d'Investigacions 
      Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de 
      Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 
      Spain.
FAU - Giralt, Albert
AU  - Giralt A
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia; Institut d'Investigacions 
      Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de 
      Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 
      Spain.
FAU - Alberch, Jordi
AU  - Alberch J
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia; Institut d'Investigacions 
      Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de 
      Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 
      Spain.
FAU - Perez-Navarro, Esther
AU  - Perez-Navarro E
AD  - Departament de Biomedicina, Facultat de Medicina i Ciencies de la Salut, Institut 
      de Neurociencies, Universitat de Barcelona, Catalonia; Institut d'Investigacions 
      Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de 
      Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 
      Spain. Electronic address: estherperez@ub.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171106
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/deficiency/*physiology
MH  - Corpus Striatum/growth & development/*metabolism
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Protein Tyrosine Phosphatases/*metabolism
OTO - NOTNLM
OT  - Aging
OT  - STEP
OT  - Sex
OT  - Striatum
OT  - Ubiquitination
EDAT- 2017/11/11 06:00
MHDA- 2018/07/20 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/11/05 00:00 [accepted]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/07/20 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - S1044-7431(17)30245-2 [pii]
AID - 10.1016/j.mcn.2017.11.003 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2018 Jan;86:41-49. doi: 10.1016/j.mcn.2017.11.003. Epub 2017 
      Nov 6.