PMID- 29124528 OWN - NLM STAT- MEDLINE DCOM- 20190104 LR - 20190104 IS - 1573-7322 (Electronic) IS - 1382-4147 (Linking) VI - 23 IP - 1 DP - 2018 Jan TI - Systematic review of economic burden of heart failure. PG - 131-145 LID - 10.1007/s10741-017-9661-0 [doi] AB - The aim of this study is to perform a systematic review of the costing methodological approaches adopted by published cost-of-illness (COI) studies. A systematic review was performed to identify cost-of-illness studies of heart failure published between January 2003 and September 2015 via computerized databases such as Pubmed, Wiley Online, Science Direct, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Costs reported in the original studies were converted to 2014 international dollars (Int$). Thirty five out of 4972 studies met the inclusion criteria. Nineteen out of the 35 studies reported the costs as annual cost per patient, ranging from Int$ 908.00 to Int$ 84,434.00, while nine studies reported costs as per hospitalization, ranging from Int$ 3780.00 to Int$ 34,233.00. Cost of heart failure increased as condition of heart failure worsened from New York Heart Association (NYHA) class I to NYHA class IV. Hospitalization cost was found to be the main cost driver to the total health care cost. The annual cost of heart failure ranges from Int$ 908 to Int$ 40,971 per patient. The reported cost estimates were inconsistent across the COI studies, mainly due to the variation in term of methodological approaches such as disease definition, epidemiological approach of study, study perspective, cost disaggregation, estimation of resource utilization, valuation of unit cost components, and data sources used. Such variation will affect the reliability, consistency, validity, and relevance of the cost estimates across studies. FAU - Shafie, Asrul Akmal AU - Shafie AA AD - Discipline of Social Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia. aakmal@usm.my. FAU - Tan, Yui Ping AU - Tan YP AD - Discipline of Social Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia. FAU - Ng, Chin Hui AU - Ng CH AD - Discipline of Social Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia. LA - eng PT - Journal Article PT - Systematic Review PL - United States TA - Heart Fail Rev JT - Heart failure reviews JID - 9612481 SB - IM MH - *Cost of Illness MH - Health Care Costs/*trends MH - Heart Failure/*economics MH - Humans OTO - NOTNLM OT - Cost-of-illness study OT - Economic burden OT - Heart failure OT - Hospitalization cost EDAT- 2017/11/11 06:00 MHDA- 2019/01/05 06:00 CRDT- 2017/11/11 06:00 PHST- 2017/11/11 06:00 [pubmed] PHST- 2019/01/05 06:00 [medline] PHST- 2017/11/11 06:00 [entrez] AID - 10.1007/s10741-017-9661-0 [pii] AID - 10.1007/s10741-017-9661-0 [doi] PST - ppublish SO - Heart Fail Rev. 2018 Jan;23(1):131-145. doi: 10.1007/s10741-017-9661-0.