PMID- 29124763
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190409
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Linking)
VI  - 526
IP  - 4
DP  - 2018 Mar 1
TI  - Neuronal expression of brain derived neurotrophic factor in the injured 
      telencephalon of adult zebrafish.
PG  - 569-582
LID - 10.1002/cne.24352 [doi]
AB  - The reparative ability of the central nervous system varies widely in the animal 
      kingdom. In the mammalian brain, the regenerative mechanisms are very limited and 
      newly formed neurons do not survive longer, probably due to a non-suitable local 
      environment. On the opposite, fish can repair the brain after injury, with fast 
      and complete recovery of damaged area. The brain of zebrafish, a teleost fish 
      widely used as vertebrate model, also possesses high regenerative properties 
      after injury. Taking advantage of this relevant model, the aim of the present 
      study was to investigate the role of brain-derived neurotrophic factor (BDNF) in 
      the regenerative ability of adult brain, after stab wound telencephalic injury. 
      BDNF is involved in many brain functions and plays key roles in the repair 
      process after traumatic brain lesions. It has been reported that BDNF strengthens 
      the proliferative activity of neuronal precursor cells, facilitates the neuronal 
      migration toward injured areas, and shows survival properties due to its 
      anti-apoptotic effects. BDNF mRNA levels, assessed by quantitative PCR and in 
      situ hybridization at 1, 4, 7, and 15 days after the lesion, were increased in 
      the damaged telencephalon, mostly suddenly after the lesion. Double staining 
      using in situ hybridization and immunocytochemistry revealed that BDNF mRNA was 
      restricted to cells identified as mature neurons. BDNF mRNA expressing neurons 
      mostly increased in the area around the lesion, showing a peak 1 day after the 
      lesion. Taken together, these results highlight the role of BDNF in brain repair 
      processes and reinforce the value of zebrafish for the study of regenerative 
      neurogenesis.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Cacialli, Pietro
AU  - Cacialli P
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, Napoli, Italy.
AD  - Inserm, UMR 1085, Research Institute in Health, Environment and Occupation, SFR 
      Biosit, University of Rennes 1, Rennes, France.
FAU - D'angelo, Livia
AU  - D'angelo L
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, Napoli, Italy.
FAU - Kah, Olivier
AU  - Kah O
AD  - Inserm, UMR 1085, Research Institute in Health, Environment and Occupation, SFR 
      Biosit, University of Rennes 1, Rennes, France.
FAU - Coumailleau, Pascal
AU  - Coumailleau P
AD  - Inserm, UMR 1085, Research Institute in Health, Environment and Occupation, SFR 
      Biosit, University of Rennes 1, Rennes, France.
FAU - Gueguen, Marie-Madeleine
AU  - Gueguen MM
AD  - Inserm, UMR 1085, Research Institute in Health, Environment and Occupation, SFR 
      Biosit, University of Rennes 1, Rennes, France.
FAU - Pellegrini, Elisabeth
AU  - Pellegrini E
AD  - Inserm, UMR 1085, Research Institute in Health, Environment and Occupation, SFR 
      Biosit, University of Rennes 1, Rennes, France.
FAU - Lucini, Carla
AU  - Lucini C
AUID- ORCID: 0000-0003-2216-6338
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, Napoli, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171126
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (BDNF protein, zebrafish)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Zebrafish Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Functional Laterality
MH  - Male
MH  - Nerve Regeneration/physiology
MH  - Neurons/metabolism/pathology
MH  - RNA, Messenger/metabolism
MH  - Telencephalon/*injuries/*metabolism/pathology
MH  - Wounds, Stab/metabolism/pathology
MH  - Zebrafish
MH  - Zebrafish Proteins/*metabolism
OTO - NOTNLM
OT  - AB_2633275
OT  - RRID
OT  - RRID AB_221448
OT  - RRID AB_477413
OT  - RRID AB_477585
OT  - brain
OT  - brain traumatic
OT  - fish
OT  - injury
OT  - lesion
OT  - neurotrophins
OT  - regeneration
OT  - repair
EDAT- 2017/11/11 06:00
MHDA- 2019/03/12 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/10/17 00:00 [revised]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - 10.1002/cne.24352 [doi]
PST - ppublish
SO  - J Comp Neurol. 2018 Mar 1;526(4):569-582. doi: 10.1002/cne.24352. Epub 2017 Nov 
      26.