PMID- 29124871
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181108
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 34
IP  - 2
DP  - 2018 Feb
TI  - Low triglyceride as a marker for increased risk of cardiovascular diseases in 
      patients with long-term type 2 diabetes: A cross-sectional survey in China.
LID - 10.1002/dmrr.2960 [doi]
AB  - BACKGROUND: There are inconsistent findings regarding associations between 
      triglyceride levels and cardiovascular disease (CVD) in type 2 diabetes mellitus 
      (T2DM). This study aimed to test whether the association between triglycerides 
      and CVD depends upon duration of diabetes. METHODS: From April 1, 2012, to June 
      30, 2012, we conducted a cross-sectional survey of 223 612 patients with T2DM 
      from 630 hospitals in China. Cardiovascular disease was defined as having either 
      prior coronary heart disease or stroke, or diabetic foot. Binary logistic 
      regression was used to estimate odds ratios of triglyceride for CVD. Relative 
      excess risk due to interaction, attributable proportion due to interaction, and 
      synergy index were used to estimate effect size of additive interaction between 
      low triglyceride, ie, <1.7 mmol/L, and duration of diabetes, ie, >/=15 years. 
      RESULTS: Among 223 612 T2DM patients, 31 898 (14.27%) suffered from CVD. A low 
      level of triglyceride was associated with decreased risk of CVD (univariable OR, 
      0.91, 95% CI, 0.88-0.93; multivariable OR, 0.94, 95% CI, 0.92-0.97) among 
      patients with <15 years of duration of diabetes but increased risk of CVD 
      (univariable OR, 1.12, 95% CI, 1.04-1.21; multivariable OR, 1.18, 95% CI, 
      1.09-1.27) among those patients with 15 and more years of duration of diabetes 
      with significant additive interactions (relative excess risk due to interaction, 
      0.39, 95% CI, 0.25-0.52; attributable proportion due to interaction, 0.20, 95% 
      CI, 0.14-0.27; and synergy index, 1.80, 95% CI, 1.43-2.28). CONCLUSIONS: Whereas 
      a high triglyceride level was associated with increased risk of CVD in short-term 
      T2DM, low triglyceride was associated with increased CVD risk in long-term T2DM. 
      Low triglyceride may be a marker of CVD risk in Chinese patients with long-term 
      T2DM.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Ren, Yanfeng
AU  - Ren Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
AD  - Department of Health Statistics, School of Public Health and Management, Weifang 
      Medical University, Shandong, China.
FAU - Ren, Qian
AU  - Ren Q
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing, China.
FAU - Lu, Juming
AU  - Lu J
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Xiaohui
AU  - Guo X
AD  - Department of Endocrinology, Peking University First Hospital, Beijing, China.
FAU - Huo, Xiaoxu
AU  - Huo X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Ji, Linong
AU  - Ji L
AUID- ORCID: 0000-0002-3262-2168
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing, China.
FAU - Yang, Xilin
AU  - Yang X
AUID- ORCID: 0000-0002-9462-7992
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171128
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Biomarkers)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/blood/*diagnosis/epidemiology/etiology
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Triglycerides/*blood
OTO - NOTNLM
OT  - Chinese
OT  - cardiovascular complications
OT  - duration
OT  - triglyceride
OT  - type 2 diabetes
EDAT- 2017/11/11 06:00
MHDA- 2018/11/09 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/10/07 00:00 [revised]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - 10.1002/dmrr.2960 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2018 Feb;34(2). doi: 10.1002/dmrr.2960. Epub 2017 Nov 28.