PMID- 29124977
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20220205
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 24
IP  - sup1
DP  - 2017
TI  - Drug delivery for bioactive polysaccharides to improve their drug-like properties 
      and curative efficacy.
PG  - 70-80
LID - 10.1080/10717544.2017.1396383 [doi]
AB  - Over several decades, natural polysaccharides (PSs) have been actively exploited 
      for their wide bioactivities. So far, many PS-related reviews have been 
      published; however, none focused on the delivery of bioactive PSs as therapeutic 
      molecules. Herein, we summarized and discussed general pharmacokinetic properties 
      of PSs and drug delivery systems (DDSs) developed for them, together with the 
      challenges and prospects. Overall, most bioactive PSs suffer from undesirable 
      pharmacokinetic attributes, which negatively affect their efficacy and clinical 
      use. Various DDSs therefore have been being utilized to improve the drug-like 
      properties and curative efficacy of bioactive PSs by means of improving oral 
      absorption, controlling the release, enhancing the in vivo retention ability, 
      targeting the delivery, exerting synergistic effects, and so on. Specifically, 
      nano-sized insoluble DDSs were mainly applied to improve the oral absorption and 
      target delivery of PSs, among which liposome was especially suitable for 
      immunoregulatory and/or anti-ischemic PSs due to its synergistic effects in 
      immunoregulation and biomembrane repair. Chemical conjugation of PSs was mainly 
      utilized to improve their oral absorption and/or prolong their blood residence. 
      With formulation flexibility, in situ forming systems alone or in combination 
      with drug conjugation could be used to achieve day(s)- or month(s)-long sustained 
      delivery of PSs per dosing.
FAU - Li, Zhe
AU  - Li Z
AD  - a College of Chinese Materia Medica , Shanghai University of Traditional Chinese 
      Medicine , Shanghai , PR China.
AD  - b Engineering Research Center of Modern Preparation Technology of TCM of Ministry 
      of Education, Shanghai University of Traditional Chinese Medicine , Shanghai , PR 
      China.
FAU - Wang, LiNa
AU  - Wang L
AD  - a College of Chinese Materia Medica , Shanghai University of Traditional Chinese 
      Medicine , Shanghai , PR China.
FAU - Lin, Xiao
AU  - Lin X
AD  - a College of Chinese Materia Medica , Shanghai University of Traditional Chinese 
      Medicine , Shanghai , PR China.
AD  - b Engineering Research Center of Modern Preparation Technology of TCM of Ministry 
      of Education, Shanghai University of Traditional Chinese Medicine , Shanghai , PR 
      China.
FAU - Shen, Lan
AU  - Shen L
AD  - a College of Chinese Materia Medica , Shanghai University of Traditional Chinese 
      Medicine , Shanghai , PR China.
FAU - Feng, Yi
AU  - Feng Y
AD  - b Engineering Research Center of Modern Preparation Technology of TCM of Ministry 
      of Education, Shanghai University of Traditional Chinese Medicine , Shanghai , PR 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Liposomes)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations/administration & dosage/chemistry
MH  - Drug Delivery Systems/methods
MH  - Humans
MH  - Liposomes/administration & dosage/chemistry
MH  - Polysaccharides/*administration & dosage/*chemistry
PMC - PMC8812577
OTO - NOTNLM
OT  - Polysaccharide
OT  - conjugation
OT  - in situ forming system
OT  - nano-sized carrier
OT  - pharmacokinetics
COIS- The authors report no conflicts of interest in this work.
EDAT- 2017/11/11 06:00
MHDA- 2018/06/26 06:00
PMCR- 2017/11/10
CRDT- 2017/11/11 06:00
PHST- 2017/11/11 06:00 [entrez]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/11/10 00:00 [pmc-release]
AID - 1396383 [pii]
AID - 10.1080/10717544.2017.1396383 [doi]
PST - ppublish
SO  - Drug Deliv. 2017;24(sup1):70-80. doi: 10.1080/10717544.2017.1396383.