PMID- 29125907
OWN - NLM
STAT- MEDLINE
DCOM- 20181220
LR  - 20221207
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Linking)
VI  - 18
IP  - 4
DP  - 2017 Dec
TI  - Risk of Type 2 Diabetes Mellitus Development in the Native Population of Low- and 
      High-Altitude Regions of Kyrgyzstan: Finnish Diabetes Risc Score Questionnaire 
      Results.
PG  - 428-435
LID - 10.1089/ham.2017.0036 [doi]
AB  - Moldobaeva, Marina S., Anastasiya V. Vinogradova, and Marina K. Esenamanova. Risk 
      of type 2 diabetes mellitus development in the native population of low- and 
      high-altitude regions of Kyrgyzstan: Finnish Diabetes Risc Score questionnaire 
      results. High Alt Med Biol. 18:428-435, 2017. OBJECTIVE: The number of patients 
      with diabetes is steadily growing, but likely only half of all cases are ever 
      identified. The Kyrgyz, native inhabitants of Central Asia, live in the 
      mountainous area and have a particular lifestyle and nutrition. However, the risk 
      of type 2 diabetes mellitus (T2DM) in our population is not well defined. 
      Therefore, we aimed at determining the risk of T2DM development in the Kyrgyz 
      population residing in low- and high-altitude (HAlt) regions by using the Finnish 
      Diabetes Risc Score (FINDRISC) questionnaire. METHODS: We included in the study 
      3190 randomly selected participants, including 1780 low-altitude (LAlt) residents 
      (Chu region, 500-1200 m) and 1410 HAlt residents (Naryn region, 2000-4500 m), 
      among whom there were 1207 men and 1983 women. Assessment of T2DM development was 
      conducted by using the FINDRISC questionnaire and risk stratification was 
      performed by region of residency, gender, and age. RESULTS: An irregular intake 
      of vegetables and fruits, increased waist circumference (WC), and increased body 
      mass index (BMI) were identified as leading risk factors of T2DM development in 
      native residents of Chu and Naryn regions of Kyrgyzstan. The 10-year risk 
      stratification of T2DM development revealed the absence of a very high-risk 
      group; high-risk status was more frequently identified among residents of the 
      LAlt Chu district (4.7% of women and 2.1% of men), as compared with the HAlt 
      population (1.9% of women and 1% of men) (p = 0.0018 for women and p = 0.09 for 
      men). CONCLUSIONS: In the Kyrgyz population, a 10-year high risk of T2DM 
      development is greater among residents of LAlts as compared with HAlts, 
      irrespective of gender. No very high-risk group was detected in residents of low 
      or HAlts. The leading composites of FINDRISC score are increased WC and BMI, 
      possibly due to irregular intake of vegetables and fruits that are dependent on 
      the altitude of residence and age.
FAU - Moldobaeva, Marina S
AU  - Moldobaeva MS
AD  - 1 Department of Internal Diseases Propedeutic with Course of Endocrinology, 
      Faculty of Medicine, Kyrgyz State Medical Academy named by I.K. Ahunbaev , 
      Bishkek, Kyrgyzstan .
FAU - Vinogradova, Anastasiya V
AU  - Vinogradova AV
AD  - 1 Department of Internal Diseases Propedeutic with Course of Endocrinology, 
      Faculty of Medicine, Kyrgyz State Medical Academy named by I.K. Ahunbaev , 
      Bishkek, Kyrgyzstan .
FAU - Esenamanova, Marina K
AU  - Esenamanova MK
AD  - 2 Department of Hygiene Disciplines, Kyrgyz State Medical Academy named by I.K. 
      Ahunbaev , Bishkek, Kyrgyzstan .
LA  - eng
PT  - Journal Article
DEP - 20171110
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - *Altitude
MH  - *Asian People
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*ethnology
MH  - Diet
MH  - Female
MH  - Humans
MH  - Kyrgyzstan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Residence Characteristics
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Waist Circumference
OTO - NOTNLM
OT  - diabetes mellitus
OT  - high altitude
OT  - low altitude
OT  - risk factors
OT  - stratification
EDAT- 2017/11/11 06:00
MHDA- 2018/12/21 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2018/12/21 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - 10.1089/ham.2017.0036 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2017 Dec;18(4):428-435. doi: 10.1089/ham.2017.0036. Epub 2017 
      Nov 10.