PMID- 29126169
OWN - NLM
STAT- MEDLINE
DCOM- 20200403
LR  - 20200403
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 21
IP  - 6
DP  - 2019 May 21
TI  - Dose-Dependent Effect of Cotinine-Verified Tobacco Smoking on Serum 
      Immunoglobulin E Levels in Korean Adult Males.
PG  - 813-817
LID - 10.1093/ntr/ntx247 [doi]
AB  - BACKGROUND: Smoking is one of the risk factors to exacerbate allergic diseases, 
      and it may affect serum immunoglobulin E (IgE) levels. However, few studies have 
      relied on an objective biomarker to examine the effect of tobacco smoking on 
      serum IgE levels. METHOD: A nationwide cross-sectional study was conducted to 
      examine the relationship between urinary cotinine (Ucot) concentrations and IgE 
      levels in 973 males using data from the 2010 Korean National Health and Nutrition 
      Examination Survey (KNHANES). Ucot was classified into four groups based on 
      concentration (ng/mL) as follows: nonsmoker group (Ucot <50 ng/mL) and three 
      tertile groups in smokers (T1 [Ucot: 50.00-921.28 ng/mL]; T2 [Ucot: 
      921.29-1869.36 ng/mL]; and T3 [Ucot >/=1869.37 ng/mL]). The dose-response 
      relationships between Ucot concentrations and total serum IgE level were 
      estimated using analysis of covariance (ANCOVA) and multiple linear regression 
      analysis after adjusting for confounding variables. RESULTS: We found a 
      significant and positive dose-related effect of cigarette smoking as measured by 
      Ucot concentrations on the total serum IgE level. The multivariate adjusted means 
      of total serum IgE levels (SE) were 321.0 (36.3), 404.4 (102.7), 499.2 (79.2), 
      and 534.7 (82.7) IU/mL, after adjusting for age, body mass index, alcohol 
      ingestion, physical exercise, job, and household income. The regression 
      coefficient beta for total serum IgE was beta = 68.6 with increasing level of Ucot 
      group after adjusting for the same covariables (p = .009). CONCLUSION: These 
      findings suggest that the amount of smoking may have a dose-dependent effect on 
      total serum IgE levels. IMPLICATION: Smoking is one of the risk factors to 
      exacerbate allergic diseases, and it may affect serum immunoglobulin E (IgE) 
      levels, which is closely related to type 1 mediated allergic diseases. However, 
      few studies have relied on an objective biomarker to examine the effect of 
      tobacco smoking on serum IgE levels. We found that tobacco exposure, as measured 
      by Ucot concentrations, increased the serum IgE levels in a dose-response manner 
      in a representative sample of Korean adult males.
CI  - (c) The Author(s) 2017. Published by Oxford University Press on behalf of the 
      Society for Research on Nicotine and Tobacco. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Dong, Jae-June
AU  - Dong JJ
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul, 
      Korea.
AD  - Department of Medicine, Graduate School, Yonsei University, Seoul, Republic of 
      Korea.
FAU - Shen, Jay J
AU  - Shen JJ
AD  - Department of Healthcare Administration and Policy, School of Community Health 
      Sciences, University of Nevada, Las Vegas, NV.
FAU - Lee, Yong-Jae
AU  - Lee YJ
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul, 
      Korea.
AD  - Department of Healthcare Administration and Policy, School of Community Health 
      Sciences, University of Nevada, Las Vegas, NV.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Adult
MH  - Biomarkers/*analysis
MH  - Body Mass Index
MH  - Cotinine/*urine
MH  - Cross-Sectional Studies
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Nutrition Surveys
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Smokers
MH  - Tobacco Smoking/*adverse effects/blood/epidemiology/urine
EDAT- 2017/11/11 06:00
MHDA- 2020/04/04 06:00
CRDT- 2017/11/11 06:00
PHST- 2017/07/07 00:00 [received]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/11/11 06:00 [pubmed]
PHST- 2020/04/04 06:00 [medline]
PHST- 2017/11/11 06:00 [entrez]
AID - 4596369 [pii]
AID - 10.1093/ntr/ntx247 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2019 May 21;21(6):813-817. doi: 10.1093/ntr/ntx247.