PMID- 29126442
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20181113
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 48
IP  - 1
DP  - 2017 Nov 10
TI  - Effect of enriched housing on levels of natural (auto-)antibodies in pigs 
      co-infected with porcine reproductive and respiratory syndrome virus (PRRSV) and 
      Actinobacillus pleuropneumoniae.
PG  - 75
LID - 10.1186/s13567-017-0481-y [doi]
LID - 75
AB  - Housing of pigs in barren, stimulus-poor housing conditions may influence their 
      immune status, including antibody responses to (auto-)antigens, and thus affect 
      immune protection, which will influence the onset and outcome of infection. In 
      the present study, we investigated the effects of environmental enrichment versus 
      barren housing on the level of natural (auto-)antibodies (NA(A)b) and their 
      isotypes (IgM and IgG) binding keyhole limpet hemocyanin (KLH), myelin basic 
      protein (MBP), and phosphorycholine conjugated to bovine serum albumin (PC-BSA) 
      in pigs co-infected with porcine reproductive and respiratory syndrome virus 
      (PRRSV) and Actinobacillus pleuropneumoniae (A. pleuropneumoniae). Pigs (n = 56) 
      were housed in either barren or enriched pens from birth to 54 days of age. They 
      were infected with PRRSV on 44 days of age, and with A. pleuropneumoniae 8 days 
      later. Blood samples were taken on 7 different sampling days. Housing 
      significantly affected the overall serum levels of NA(A)b binding KLH, MBP and 
      PC-BSA, and before infection barren housed pigs had significantly higher levels 
      of NA(A)b than enriched housed pigs, except for KLH-IgM and PC-BSA-IgG. Infection 
      only affected the IgM, but not the IgG isotype. Moreover, changes in MBP-IgM and 
      PC-BSA-IgM following infection were different for enriched and barren housed 
      pigs. These results suggest that the effect of infection on NA(A)b is influenced 
      by housing conditions and that NA(A)b, especially IgM may be affected by 
      infection.
FAU - Luo, Lu
AU  - Luo L
AD  - Adaptation Physiology Group, Department of Animal Sciences, Wageningen University 
      & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands.
FAU - van Dixhoorn, Ingrid Danielle Ellen
AU  - van Dixhoorn IDE
AD  - Wageningen Livestock Research, P.O. Box 338, 6700 AH, Wageningen, The 
      Netherlands.
FAU - Reimert, Inonge
AU  - Reimert I
AD  - Adaptation Physiology Group, Department of Animal Sciences, Wageningen University 
      & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands.
FAU - Kemp, Bas
AU  - Kemp B
AD  - Adaptation Physiology Group, Department of Animal Sciences, Wageningen University 
      & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands.
FAU - Bolhuis, Jantina Elizabeth
AU  - Bolhuis JE
AD  - Adaptation Physiology Group, Department of Animal Sciences, Wageningen University 
      & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands.
FAU - Parmentier, Hendrik Karel
AU  - Parmentier HK
AD  - Adaptation Physiology Group, Department of Animal Sciences, Wageningen University 
      & Research, P.O. Box 338, 6700 AH, Wageningen, The Netherlands. 
      henk.parmentier@wur.nl.
LA  - eng
PT  - Journal Article
DEP - 20171110
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Actinobacillus Infections/immunology/*veterinary/virology
MH  - Actinobacillus pleuropneumoniae/physiology
MH  - Animals
MH  - Antibodies, Bacterial/*immunology
MH  - Antibodies, Viral/*immunology
MH  - Autoantibodies/*immunology
MH  - Coinfection/immunology/virology
MH  - Female
MH  - *Housing, Animal
MH  - Male
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/virology
MH  - Porcine respiratory and reproductive syndrome virus/physiology
MH  - Sus scrofa/physiology
MH  - Swine
MH  - Swine Diseases/*immunology/virology
PMC - PMC5681819
EDAT- 2017/11/12 06:00
MHDA- 2018/06/26 06:00
PMCR- 2017/11/10
CRDT- 2017/11/12 06:00
PHST- 2017/05/29 00:00 [received]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/11/12 06:00 [entrez]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/11/10 00:00 [pmc-release]
AID - 10.1186/s13567-017-0481-y [pii]
AID - 481 [pii]
AID - 10.1186/s13567-017-0481-y [doi]
PST - epublish
SO  - Vet Res. 2017 Nov 10;48(1):75. doi: 10.1186/s13567-017-0481-y.