PMID- 29126696
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 79
DP  - 2018 Feb
TI  - Coordination of mitochondrial biogenesis by PGC-1alpha in human skeletal muscle: A 
      re-evaluation.
PG  - 42-51
LID - S0026-0495(17)30303-7 [pii]
LID - 10.1016/j.metabol.2017.11.001 [doi]
AB  - The transcriptional co-activator peroxisome proliferator-activated receptor gamma 
      co-activator-1 alpha (PGC-1alpha) is proposed to coordinate skeletal muscle 
      mitochondrial biogenesis through the integrated induction of nuclear- and 
      mitochondrial-encoded gene transcription. This paradigm is based largely on 
      experiments demonstrating PGC-1alpha's ability to co-activate various nuclear 
      transcription factors that increase the expression of mitochondrial genes, as 
      well as PGC-1alpha's direct interaction with mitochondrial transcription factor A 
      within mitochondria to increase the transcription of mitochondrial DNA. While 
      this paradigm is supported by evidence from cellular and transgenic animal 
      models, as well as acute exercise studies involving animals, the up-regulation of 
      nuclear- and mitochondrial-encoded genes in response to exercise does not appear 
      to occur in a coordinated fashion in human skeletal muscle. This review 
      re-evaluates our current understanding of this phenomenon by highlighting 
      evidence from recent studies examining the exercise-induced expression of 
      nuclear- and mitochondrial-encoded genes targeted by PGC-1alpha. We also highlight 
      several possible theories that may explain the apparent inability of PGC-1alpha to 
      coordinately up-regulate the expression of genes required for mitochondrial 
      biogenesis in human skeletal muscle, and provide directions for future work 
      exploring mitochondrial biogenic gene expression following exercise.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Islam, Hashim
AU  - Islam H
AD  - School of Kinesiology and Health Studies, Queen's University, Kingston K7L 3N6, 
      Ontario, Canada. Electronic address: hashim.islam@queensu.ca.
FAU - Edgett, Brittany A
AU  - Edgett BA
AD  - School of Kinesiology and Health Studies, Queen's University, Kingston K7L 3N6, 
      Ontario, Canada; Human Health and Nutritional Sciences, University of Guelph, 
      Guelph N1G 2W1, Ontario, Canada. Electronic address: b.edgett@queensu.ca.
FAU - Gurd, Brendon J
AU  - Gurd BJ
AD  - School of Kinesiology and Health Studies, Queen's University, Kingston K7L 3N6, 
      Ontario, Canada. Electronic address: gurdb@queensu.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171108
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
SB  - IM
MH  - Exercise
MH  - Humans
MH  - Mitochondria, Muscle/metabolism/*physiology
MH  - Muscle, Skeletal/*growth & development/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
OTO - NOTNLM
OT  - Exercise metabolism
OT  - Mitochondrial gene regulation
OT  - PGC-1alpha
OT  - Skeletal muscle physiology
OT  - TFAM
EDAT- 2017/11/12 06:00
MHDA- 2018/10/23 06:00
CRDT- 2017/11/12 06:00
PHST- 2017/08/15 00:00 [received]
PHST- 2017/10/13 00:00 [revised]
PHST- 2017/11/01 00:00 [accepted]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2017/11/12 06:00 [entrez]
AID - S0026-0495(17)30303-7 [pii]
AID - 10.1016/j.metabol.2017.11.001 [doi]
PST - ppublish
SO  - Metabolism. 2018 Feb;79:42-51. doi: 10.1016/j.metabol.2017.11.001. Epub 2017 Nov 
      8.