PMID- 29126878
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 195
DP  - 2018 Mar
TI  - Dendritic cells in systemic sclerosis: Advances from human and mice studies.
PG  - 18-29
LID - S0165-2478(17)30290-0 [pii]
LID - 10.1016/j.imlet.2017.11.003 [doi]
AB  - Systemic sclerosis (SSc) is a complex heterogeneous fibrotic autoimmune disease 
      with an unknown exact etiology, and characterized by three hallmarks: fibrosis, 
      vasculopathy, and immune dysfunction. Dendritic cells (DCs) are specialized cells 
      in pathogen sensing with high potency of antigen presentation and capable of 
      releasing mediators to shape the immune response. Altered DCs distributions and 
      their impaired functions may account for their role in breaking the immune 
      tolerance and driving inflammation in SSc, and the direct contribution of DCs in 
      promoting endothelial dysfunction and fibrotic process has only begun to be 
      understood. Plasmacytoid dendritic cells in particular have been implicated due 
      to their high production of type I interferon as well as other cytokines and 
      chemokines, including the pro-inflammatory and anti-angiogenic CXCL4. 
      Furthermore, a deeper understanding of human and mouse DC biology has clarified 
      their identification and function in different tissues, and novel DC subsets have 
      only recently been discovered. In this review, we highlight key findings and 
      recent advances exploring DC role in the pathogenesis of SSc and other related 
      autoimmune diseases, and consideration of their potential use as targeted therapy 
      in SSc.
CI  - Copyright (c) 2017 European Federation of Immunological Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Affandi, Alsya J
AU  - Affandi AJ
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht University, Utrecht, The Netherlands; Department of Rheumatology and 
      Clinical Immunology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Carvalheiro, Tiago
AU  - Carvalheiro T
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht University, Utrecht, The Netherlands; Department of Rheumatology and 
      Clinical Immunology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Radstake, Timothy R D J
AU  - Radstake TRDJ
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht University, Utrecht, The Netherlands; Department of Rheumatology and 
      Clinical Immunology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Marut, Wioleta
AU  - Marut W
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht University, Utrecht, The Netherlands; Department of Rheumatology and 
      Clinical Immunology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands. Electronic address: W.K.Marut@umcutrecht.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171107
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 37270-94-3 (Platelet Factor 4)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Inflammation/*immunology
MH  - Mice
MH  - Models, Animal
MH  - Platelet Factor 4/metabolism
MH  - Scleroderma, Systemic/*immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Fibrosis
OT  - Inflammation
OT  - Pathogenesis
OT  - Systemic sclerosis
EDAT- 2017/11/12 06:00
MHDA- 2019/01/29 06:00
CRDT- 2017/11/12 06:00
PHST- 2017/06/21 00:00 [received]
PHST- 2017/11/05 00:00 [revised]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2017/11/12 06:00 [entrez]
AID - S0165-2478(17)30290-0 [pii]
AID - 10.1016/j.imlet.2017.11.003 [doi]
PST - ppublish
SO  - Immunol Lett. 2018 Mar;195:18-29. doi: 10.1016/j.imlet.2017.11.003. Epub 2017 Nov 
      7.