PMID- 29126931
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20181202
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 339
DP  - 2018 Feb 26
TI  - Phytochemical allylguaiacol exerts a neuroprotective effect on hippocampal cells 
      and ameliorates scopolamine-induced memory impairment in mice.
PG  - 261-268
LID - S0166-4328(17)31467-5 [pii]
LID - 10.1016/j.bbr.2017.11.003 [doi]
AB  - Allylguaiacol is a phytochemical occurring in various plants such as cloves, 
      cinnamon, basil, and nutmeg. Pharmacological effects of allylguaiacol include 
      antimicrobial, anti-inflammatory, anticancer, antioxidant, and neuroprotective 
      activity. Although allylguaiacol is considered to have neuroprotective effects, 
      there is no report on its regulatory mechanisms at the molecular level. In the 
      present study, we investigated the mechanisms of allylguaiacol as an antioxidant 
      and neuroprotective agent using hydrogen peroxide (H(2)O(2))-treated HT22 
      hippocampal cells. Allylguaiacol increased the scavenging activities of free 
      radicals 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 
      2,2-diphenyl-1-picrylhydrazyl (DPPH), and enhanced the expression of antioxidant 
      enzymes manganese superoxide dismutase (MnSOD) and catalase. In addition, 
      allylguaiacol inhibited H(2)O(2)-induced damage of HT22 with increasing 
      production of brain-derived neurotrophic factor (BDNF), phosphorylation of 
      phosphoinositide 3-kinase (PI3K), and cyclic AMP response element-binding protein 
      (CREB). Furthermore, antibody microarray data revealed that phospho-regulation of 
      nuclear factor kappa B (NF-kappaB) p65 and death domain-associated protein (DAXX) is 
      involved in protection against neuronal cell damage. In a mouse model of 
      short-term memory impairment, allylguaiacol (2.5 or 5mg/kg) significantly 
      ameliorated scopolamine-mediated cognitive impairment in a passive avoidance 
      task. In addition, allylguaiacol significantly increased the expression of TrkA 
      and B in the hippocampus from scopolamine-treated mice. Taken together, our 
      findings suggest that allylguaiacol exerts a neuroprotective effect through the 
      antioxidant activation and protein regulation of NF-kappaB p65 and DAXX-related 
      signaling. The ameliorating effect of allylguaiacol may be useful for treatment 
      of memory impairment in Alzheimer's and its related diseases.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lim, Hye-Sun
AU  - Lim HS
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Republic of Korea.
FAU - Kim, Bu-Yeo
AU  - Kim BY
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Republic of Korea.
FAU - Kim, Yu Jin
AU  - Kim YJ
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Republic of Korea; College of Pharmacy, Chungnam National University, 
      Daejeon 34134, Republic of Korea.
FAU - Jeong, Soo-Jin
AU  - Jeong SJ
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Republic of Korea; Korean Medicine of Life Science, University of Science 
      & Technology, Daejeon 34113, Republic of Korea. Electronic address: 
      sjijeong@kiom.re.kr.
LA  - eng
PT  - Journal Article
DEP - 20171108
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antioxidants)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Phytochemicals)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Avoidance Learning/*drug effects
MH  - Cholinergic Antagonists/pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Hydrogen Peroxide/metabolism/pharmacology
MH  - Memory Disorders/chemically induced/*physiopathology
MH  - Mice
MH  - Neuroprotective Agents/*pharmacology
MH  - Phosphatidylinositol 3-Kinases/drug effects/metabolism
MH  - Phytochemicals/pharmacology
MH  - Scopolamine/*pharmacology
OTO - NOTNLM
OT  - Allylguaiacol
OT  - Alzheimer's diseases
OT  - Memory impairment
OT  - Neuroprotective effect
OT  - Scopolamine
EDAT- 2017/11/12 06:00
MHDA- 2018/08/08 06:00
CRDT- 2017/11/12 06:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/10/31 00:00 [revised]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2017/11/12 06:00 [entrez]
AID - S0166-4328(17)31467-5 [pii]
AID - 10.1016/j.bbr.2017.11.003 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 Feb 26;339:261-268. doi: 10.1016/j.bbr.2017.11.003. Epub 
      2017 Nov 8.