PMID- 29127193
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20220409
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 32
IP  - 3
DP  - 2018 Mar
TI  - Maintained exercise-enhanced brain executive function related to cerebral lactate 
      metabolism in men.
PG  - 1417-1427
LID - 10.1096/fj.201700381RR [doi]
AB  - High-intensity interval exercise (HIIE) improves cerebral executive function 
      (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps 
      because of lower lactate availability for the brain. This investigation examined 
      whether improved EF after exercise relates to brain lactate uptake. Fourteen 
      healthy, male subjects performed 2 HIIE protocols separated by 60 min of rest. 
      Blood samples were obtained from the right internal jugular venous bulb and from 
      the brachial artery to determine arterial-venous differences across the brain for 
      lactate (a-v diff(lactate)), glucose (a-v diff(glucose)), oxygen (a-v 
      diff(oxygen)), and brain-derived neurotrophic factor (BDNF; a-v diff(BDNF)). EF 
      was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 
      min, whereas the second HIIE improved EF only immediately after exercise. The a-v 
      diff(glucose) was unchanged, whereas the a-v diff(BDNF) increased similarly after 
      both HIIEs, and the a-v diff(lactate) increased, but the increase was attenuated 
      after the second HIIE, compared with the first HIIE ( P < 0.05). The EF after 
      HIIE correlated with the a-v diff(lactate) ( r(2) = 0.62; P < 0.01). We propose 
      that attenuated improvement in EF after repeated HIIE relates to reduced cerebral 
      lactate metabolism and is, thereby, linked to systemic metabolism as an example 
      of the lactate shuttle mechanism.-Hashimoto, T., Tsukamoto, H., Takenaka, S., 
      Olesen, N. D., Petersen, L. G., Sorensen, H., Nielsen, H. B., Secher, N. H., 
      Ogoh, S. Maintained exercise-enhanced brain executive function related to 
      cerebral lactate metabolism in men.
FAU - Hashimoto, Takeshi
AU  - Hashimoto T
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Shiga, 
      Japan.
FAU - Tsukamoto, Hayato
AU  - Tsukamoto H
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Shiga, 
      Japan.
AD  - Japan Society for the Promotion of Science, Tokyo, Japan.
FAU - Takenaka, Saki
AU  - Takenaka S
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Shiga, 
      Japan.
FAU - Olesen, Niels D
AU  - Olesen ND
AD  - Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark; and.
FAU - Petersen, Lonnie G
AU  - Petersen LG
AD  - Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Sorensen, Henrik
AU  - Sorensen H
AD  - Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark; and.
FAU - Nielsen, Henning B
AU  - Nielsen HB
AD  - Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark; and.
FAU - Secher, Niels H
AU  - Secher NH
AD  - Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, 
      University of Copenhagen, Copenhagen, Denmark; and.
FAU - Ogoh, Shigehiko
AU  - Ogoh S
AD  - Graduate School of Engineering, Toyo University, Saitama, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180103
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Adult
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Exercise/*physiology
MH  - Humans
MH  - Lactic Acid/*blood
MH  - Male
MH  - Time Factors
OTO - NOTNLM
OT  - brain energy uptake
OT  - brain-derived neurotrophic factor
OT  - cognitive function
OT  - glucose
OT  - high-intensity interval exercise
EDAT- 2017/11/12 06:00
MHDA- 2018/11/07 06:00
CRDT- 2017/11/12 06:00
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2017/11/12 06:00 [entrez]
AID - fj.201700381RR [pii]
AID - 10.1096/fj.201700381RR [doi]
PST - ppublish
SO  - FASEB J. 2018 Mar;32(3):1417-1427. doi: 10.1096/fj.201700381RR. Epub 2018 Jan 3.