PMID- 29127341
OWN - NLM
STAT- MEDLINE
DCOM- 20190703
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Nov 10
TI  - Classification Rule for 5-year Cardiovascular Diseases Risk using decision tree 
      in Primary Care Chinese Patients with Type 2 Diabetes Mellitus.
PG  - 15238
LID - 10.1038/s41598-017-15579-z [doi]
LID - 15238
AB  - Cardiovascular disease(CVD) is the leading cause of mortality among patients with 
      type 2 diabetes mellitus(T2DM), and a risk classification model for CVD among 
      primary care diabetic patients is pivotal for risk-based interventions and 
      patient information. This study developed a simple tool for a 5-year CVD risk 
      prediction for primary care Chinese patients with T2DM. A retrospective cohort 
      study was conducted on 137,935 primary care Chinese T2DM patients aged 18-79 
      years without history of CVD between 1 January 2010 and 31 December 2010. New 
      events of CVD of the cohort over a median follow up of 5 years were extracted 
      from the medical records. A classification rule of 5-year CVD risk was obtained 
      from the derivation cohort and validated in the validation cohort. Significant 
      risk factors included in decision tree were age, gender, smoking status, 
      diagnosis duration, obesity, unsatisfactory control on haemoglobin A1c and 
      cholesterol, albuminuria and stage of chronic kidney disease, which categorized 
      patients into five 5-year CVD risk groups(<5%; 5-9%; 10-14%; 15-19% and >/=20%). 
      Taking the group with the lowest CVD risk, the hazard ratios varied from 
      1.92(1.77,2.08) to 8.46(7.75,9.24). The present prediction model performed 
      comparable discrimination and better calibration from the plot compared to other 
      current existing models.
FAU - Wan, Eric Yuk Fai
AU  - Wan EYF
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
FAU - Fong, Daniel Yee Tak
AU  - Fong DYT
AD  - School of Nursing, the University of Hong Kong, Hong Kong, China. dytfong@hku.hk.
FAU - Fung, Colman Siu Cheung
AU  - Fung CSC
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
FAU - Yu, Esther Yee Tak
AU  - Yu EYT
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
FAU - Chin, Weng Yee
AU  - Chin WY
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
FAU - Chan, Anca Ka Chun
AU  - Chan AKC
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
FAU - Lam, Cindy Lo Kuen
AU  - Lam CLK
AD  - Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F 
      Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20171110
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - *Cardiovascular Diseases/classification/epidemiology/metabolism/pathology
MH  - China/epidemiology
MH  - Cohort Studies
MH  - *Decision Trees
MH  - *Diabetes Mellitus, Type 2/classification/epidemiology/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Primary Health Care
MH  - Proportional Hazards Models
MH  - Risk Factors
PMC - PMC5681694
COIS- The authors declare that they have no competing interests.
EDAT- 2017/11/12 06:00
MHDA- 2019/07/04 06:00
PMCR- 2017/11/10
CRDT- 2017/11/12 06:00
PHST- 2017/05/10 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2017/11/12 06:00 [entrez]
PHST- 2017/11/12 06:00 [pubmed]
PHST- 2019/07/04 06:00 [medline]
PHST- 2017/11/10 00:00 [pmc-release]
AID - 10.1038/s41598-017-15579-z [pii]
AID - 15579 [pii]
AID - 10.1038/s41598-017-15579-z [doi]
PST - epublish
SO  - Sci Rep. 2017 Nov 10;7(1):15238. doi: 10.1038/s41598-017-15579-z.