PMID- 29127496 OWN - NLM STAT- MEDLINE DCOM- 20180319 LR - 20210617 IS - 1432-2307 (Electronic) IS - 0945-6317 (Linking) VI - 472 IP - 1 DP - 2018 Jan TI - Classification of eosinophilic disorders of the small and large intestine. PG - 15-28 LID - 10.1007/s00428-017-2249-1 [doi] AB - Eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic gastroenteritis and eosinophilic colitis, have been increasing in prevalence in Western countries in recent years. Eosinophils are normally scanty in the gastrointestinal tract, and increased numbers of eosinophils can denote pathology. Normal values for tissue eosinophils vary widely between different segments of the colon, thus location of the biopsy is critically important for the interpretation of findings. However, no standard diagnostic criteria have been proposed for the diagnosis of eosinophilic gastroenteritis or eosinophilic colitis. Gut eosinophilia encompasses entitites that are predominantly immunoglobulin E (IgE)-mediated, the primary EGIDs and those that are secondary and not IgE-mediated. A final diagnosis of eosinophilic gastrointestinal diseases requires careful pathological assessment, clinical correlation and exclusion of several differential diagnoses. FAU - McCarthy, Aoife J AU - McCarthy AJ AD - Department of Histopathology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland. aoifejmccarthy@hotmail.com. AD - School of Medicine, University College Dublin, Dublin, Ireland. aoifejmccarthy@hotmail.com. FAU - Sheahan, Kieran AU - Sheahan K AD - Department of Histopathology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland. AD - School of Medicine, University College Dublin, Dublin, Ireland. LA - eng PT - Journal Article DEP - 20171110 PL - Germany TA - Virchows Arch JT - Virchows Archiv : an international journal of pathology JID - 9423843 RN - Eosinophilic enteropathy SB - IM MH - Enteritis/*classification/diagnosis/pathology MH - Eosinophilia/*classification/diagnosis/pathology MH - Gastritis/*classification/diagnosis/pathology MH - Humans MH - Intestine, Large/pathology MH - Intestine, Small/pathology OTO - NOTNLM OT - Colitis OT - Enteritis OT - Eosinophilic OT - Eosinophils OT - Gastroenteritis OT - Intestine EDAT- 2017/11/12 06:00 MHDA- 2018/03/20 06:00 CRDT- 2017/11/12 06:00 PHST- 2017/06/29 00:00 [received] PHST- 2017/10/18 00:00 [accepted] PHST- 2017/09/19 00:00 [revised] PHST- 2017/11/12 06:00 [pubmed] PHST- 2018/03/20 06:00 [medline] PHST- 2017/11/12 06:00 [entrez] AID - 10.1007/s00428-017-2249-1 [pii] AID - 10.1007/s00428-017-2249-1 [doi] PST - ppublish SO - Virchows Arch. 2018 Jan;472(1):15-28. doi: 10.1007/s00428-017-2249-1. Epub 2017 Nov 10.