PMID- 29128174
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180419
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 163
IP  - 1
DP  - 2018 Jan
TI  - Health-related quality of life in MEN1 patients compared with other chronic 
      conditions and the United States general population.
PG  - 205-211
LID - S0039-6060(17)30546-9 [pii]
LID - 10.1016/j.surg.2017.04.030 [doi]
AB  - BACKGROUND: Health-related quality of life (HRQOL) in multiple endocrine 
      neoplasia type-1 (MEN-1) is poorly described. HRQOL in MEN-1 was compared with 
      other chronic conditions and the US general population. METHODS: Adults aged >/=18 
      years recruited from an MEN-1 support group (n=153) completed the 
      Patient-Reported Outcomes Measurement Information System (PROMIS) 29-item 
      profile. MEN-1 scores were compared with PROMIS scores reported in peer-reviewed 
      literature from back pain (n=218), cancer (n=310), congestive heart failure (CHF; 
      n=60), chronic obstructive pulmonary disease (COPD; n=79), major depressive 
      disorder (n=196), rheumatoid arthritis (RA; n=521), neuroendocrine tumors (NET; 
      n=619), and primary hyperparathyroidism (PHPT; n=45) cohorts. RESULTS: Patients 
      with MEN-1 reported worse anxiety (mean=61.7), depression (57.9), fatigue (62.2), 
      pain interference (55.4), sleep disturbance (58.0), physical functioning (44.4), 
      and social functioning (44.7) compared to normative data (50, P < .05) and 
      greater anxiety, depression, and fatigue than patients with back pain, cancer, 
      COPD, RA, NETs, and PHPT (P < .001). MEN-1 respondents had greater pain 
      interference (55.4) than those with cancer (51.9), NETs (52.3), and PHPT (38.4, P 
      < .05). Physical functioning was higher in individuals with MEN-1 (44.4) than in 
      those with back pain (37.5), CHF (34.8), COPD (38.0), and RA (40.7, P < .01). 
      CONCLUSION: This is the first study to describe HRQOL in a large sample of adults 
      with MEN-1. MEN-1respondents reported worse HRQOL across PROMIS 29-item profile 
      measure domains compared with the US general population and higher levels of 
      anxiety, depression, and fatigue compared with many other chronic conditions.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Peipert, Benjamin J
AU  - Peipert BJ
AD  - Department of Surgery, Northwestern University Feinberg School of Medicine, 
      Chicago, IL.
FAU - Goswami, Sneha
AU  - Goswami S
AD  - Department of Surgery, Northwestern University Feinberg School of Medicine, 
      Chicago, IL.
FAU - Yount, Susan E
AU  - Yount SE
AD  - Department of Surgery, Northwestern University Feinberg School of Medicine, 
      Chicago, IL.
FAU - Sturgeon, Cord
AU  - Sturgeon C
AD  - Department of Surgery, Northwestern University Feinberg School of Medicine, 
      Chicago, IL. Electronic address: cord.sturgeon@nm.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171108
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
CIN - Surgery. 2018 Jan;163(1):210-211. PMID: 29128191
MH  - Adult
MH  - Chronic Disease/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*psychology
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2017/11/13 06:00
MHDA- 2018/01/03 06:00
CRDT- 2017/11/13 06:00
PHST- 2017/01/26 00:00 [received]
PHST- 2017/03/26 00:00 [revised]
PHST- 2017/04/08 00:00 [accepted]
PHST- 2017/11/13 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/11/13 06:00 [entrez]
AID - S0039-6060(17)30546-9 [pii]
AID - 10.1016/j.surg.2017.04.030 [doi]
PST - ppublish
SO  - Surgery. 2018 Jan;163(1):205-211. doi: 10.1016/j.surg.2017.04.030. Epub 2017 Nov 
      8.