PMID- 29128330
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20180816
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Mar
TI  - Decreased Serum Brain-Derived Neurotrophic Factor May Indicate the Development of 
      Poststroke Depression in Patients with Acute Ischemic Stroke: A Meta-Analysis.
PG  - 709-715
LID - S1052-3057(17)30554-2 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2017.10.003 [doi]
AB  - BACKGROUND: Depression is a common complication after stroke and has been 
      associated with poor outcome. Thus, it is of great importance to identify 
      potential biomarkers that can aid in predicting and detecting patients with 
      stroke at high risk of poststroke depression (PSD) development. Previous studies 
      showed that brain-derived neurotrophic factor (BDNF) had potential use as a 
      biomarker for discriminating patients with stroke at high risk of PSD. However, 
      the results were inconsistent. METHODS: A meta-analysis was performed to evaluate 
      the correlation between the peripheral BDNF levels and the development of PSD in 
      the acute stage of stroke. RESULTS: Data were obtained from 4 studies including 
      499 patients with stroke. Among them, 171 patients were diagnosed with PSD at 
      follow-ups. Our results showed that patients with stroke who were predisposed to 
      developing PSD had significantly lower serum BDNF concentrations at the early 
      stage of stroke. CONCLUSIONS: This study suggests a potential association between 
      circulating BDNF concentrations at admission and subsequent PSD development, and 
      provides additional support for the involvement of BDNF in the PSD development.
CI  - Copyright (c) 2018 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Xu, Hong-Bo
AU  - Xu HB
AD  - Department of Critical Care Medicine, Nanshan People's Hospital, Shenzhen 518052, 
      China. Electronic address: xuhb1012@foxmail.com.
FAU - Xu, Yu-Hong
AU  - Xu YH
AD  - Department of Pharmacy, The Eighth Affiliated Hospital, Sun Yat-Sen University, 
      Shenzhen 518033, China.
FAU - He, Ying
AU  - He Y
AD  - Department of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen 
      University, Shenzhen 518033, China.
FAU - Xue, Fang
AU  - Xue F
AD  - Department of Critical Care Medicine, Nanshan People's Hospital, Shenzhen 518052, 
      China.
FAU - Wei, Jing
AU  - Wei J
AD  - Department of Critical Care Medicine, Nanshan People's Hospital, Shenzhen 518052, 
      China.
FAU - Zhang, Haigang
AU  - Zhang H
AD  - Department of Critical Care Medicine, Nanshan People's Hospital, Shenzhen 518052, 
      China.
FAU - Wu, Jinglan
AU  - Wu J
AD  - Department of Critical Care Medicine, Nanshan People's Hospital, Shenzhen 518052, 
      China. Electronic address: doctorwu99@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20171108
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/complications/diagnosis/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chi-Square Distribution
MH  - Depression/*blood/diagnosis/etiology/psychology
MH  - Down-Regulation
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Stroke/*blood/complications/diagnosis/psychology
OTO - NOTNLM
OT  - BDNF
OT  - Poststroke depression
OT  - biomarker
OT  - meta-analysis
EDAT- 2017/11/13 06:00
MHDA- 2018/07/26 06:00
CRDT- 2017/11/13 06:00
PHST- 2017/07/06 00:00 [received]
PHST- 2017/09/26 00:00 [revised]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/11/13 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
PHST- 2017/11/13 06:00 [entrez]
AID - S1052-3057(17)30554-2 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2017.10.003 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2018 Mar;27(3):709-715. doi: 
      10.1016/j.jstrokecerebrovasdis.2017.10.003. Epub 2017 Nov 8.