PMID- 29128966
OWN - NLM
STAT- MEDLINE
DCOM- 20180808
LR  - 20180808
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 310
IP  - 1
DP  - 2018 Jan
TI  - Is the DLQI appropriate for medical decision-making in psoriasis patients?
PG  - 47-55
LID - 10.1007/s00403-017-1794-4 [doi]
AB  - Dermatology Life Quality Index (DLQI) is the most commonly applied measure of 
      health-related quality of life (HRQoL) in psoriasis patients. It is among 
      defining criteria of moderate-to-severe psoriasis and present in treatment 
      guidelines. Our objective was to estimate preference-based HRQoL values (i.e., 
      utilities) for hypothetical health states described by the 10 items of the DLQI 
      in psoriasis patients. Moreover, we compare results to findings of a similar 
      study previously conducted among the general public. A cross-sectional survey was 
      carried out among 238 psoriasis patients. Seven hypothetical DLQI-defined health 
      states with total scores of 6, 11, and 16 (3-3 and 1 states, respectively) were 
      evaluated by time trade-off method. The difference in DLQI scores between 
      hypothetical health states was set at 5 points, as it exceeds the minimal 
      clinically important difference (MCID). Utility scores were found to be 
      homogenous across the seven hypothetical health states (range of means for the 
      6-point states 0.85-0.91, range of means for the 11-point states 0.83-0.85, and 
      mean of 0.84 for the 16-point state). Overall, mean utilities assessed by 
      psoriasis patients were higher for all seven states compared with the general 
      public (mean difference 0.16-0.28; p < 0.001). In 11 out of the 15 comparisons 
      between health states with DLQI scores differing larger than the MCID, there was 
      no statistically significant difference in utility. Thus, in clinical settings, 
      patients with DLQI scores differing more than the MCID may have identical HRQoL. 
      Improving the definition of moderate-to-severe disease and reconsideration of the 
      DLQI in clinical assessment of psoriasis patients are suggested.
FAU - Poor, Adrienn Katalin
AU  - Poor AK
AD  - Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, 
      Semmelweis University, Maria utca 41, 1085, Budapest, Hungary.
FAU - Brodszky, Valentin
AU  - Brodszky V
AUID- ORCID: 0000-0002-6095-2295
AD  - Department of Health Economics, Corvinus University of Budapest, Fovam ter 8, 
      1093, Budapest, Hungary.
FAU - Pentek, Marta
AU  - Pentek M
AUID- ORCID: 0000-0001-9636-6012
AD  - Department of Health Economics, Corvinus University of Budapest, Fovam ter 8, 
      1093, Budapest, Hungary.
FAU - Gulacsi, Laszlo
AU  - Gulacsi L
AUID- ORCID: 0000-0002-9285-8746
AD  - Department of Health Economics, Corvinus University of Budapest, Fovam ter 8, 
      1093, Budapest, Hungary.
FAU - Ruzsa, Gabor
AU  - Ruzsa G
AUID- ORCID: 0000-0002-6817-6454
AD  - Institute of Psychology, Doctoral School of Psychology, Eotvos Lorand University 
      of Sciences, Izabella utca 46, 1064, Budapest, Hungary.
AD  - Department of Statistics, Corvinus University of Budapest, Fovam ter 8, 1093, 
      Budapest, Hungary.
FAU - Hidvegi, Bernadett
AU  - Hidvegi B
AD  - Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, 
      Semmelweis University, Maria utca 41, 1085, Budapest, Hungary.
FAU - Hollo, Peter
AU  - Hollo P
AD  - Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, 
      Semmelweis University, Maria utca 41, 1085, Budapest, Hungary.
FAU - Karpati, Sarolta
AU  - Karpati S
AUID- ORCID: 0000-0002-8472-0712
AD  - Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, 
      Semmelweis University, Maria utca 41, 1085, Budapest, Hungary.
FAU - Sardy, Miklos
AU  - Sardy M
AUID- ORCID: 0000-0003-4306-5093
AD  - Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, 
      Semmelweis University, Maria utca 41, 1085, Budapest, Hungary.
FAU - Rencz, Fanni
AU  - Rencz F
AUID- ORCID: 0000-0001-9674-620X
AD  - Department of Health Economics, Corvinus University of Budapest, Fovam ter 8, 
      1093, Budapest, Hungary. fanni.rencz@uni-corvinus.hu.
LA  - eng
PT  - Journal Article
DEP - 20171111
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Clinical Decision-Making/*methods
MH  - Cross-Sectional Studies
MH  - Dermatology/*methods/standards
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - Psoriasis/*diagnosis/therapy
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Dermatology Life Quality Index
OT  - Health-related quality of life
OT  - Medical decision-making
OT  - Psoriasis
OT  - Time trade-off
OT  - Utility
EDAT- 2017/11/13 06:00
MHDA- 2018/08/09 06:00
CRDT- 2017/11/13 06:00
PHST- 2017/08/13 00:00 [received]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/10/28 00:00 [revised]
PHST- 2017/11/13 06:00 [pubmed]
PHST- 2018/08/09 06:00 [medline]
PHST- 2017/11/13 06:00 [entrez]
AID - 10.1007/s00403-017-1794-4 [pii]
AID - 10.1007/s00403-017-1794-4 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2018 Jan;310(1):47-55. doi: 10.1007/s00403-017-1794-4. Epub 
      2017 Nov 11.