PMID- 29128987
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 39
IP  - 2
DP  - 2018 Feb
TI  - Comparison of olfactory and gustatory disorders in Alzheimer's disease.
PG  - 321-328
LID - 10.1007/s10072-017-3187-z [doi]
AB  - Patients with Alzheimer's disease (AD) develop olfactory and gustatory disorders. 
      However, the order of failure and relevance of the pathophysiology are unclear. 
      We compared olfactory identification and whole mouth gustation in patients with 
      AD to those with mild cognitive impairment (MCI) and to healthy controls (HC) and 
      assessed correlations with pathophysiology. Patients with AD (n = 40), MCI 
      (n = 34), and HC (n = 40) were recruited. We performed the Odor Stick 
      Identification Test for Japanese (OSIT-J), gustatory test by the intraoral 
      dropping method using taste solutions, Mini-Mental State Examination (MMSE), 
      Alzheimer's Disease Assessment Scale-cognitive subscale Japanese version (ADAS-J 
      cog), Touch Panel-type Dementia Assessment Scale (TDAS), and measurement of 
      amyloid beta (Abeta) 42 and phosphorylated tau (p-tau) 181 levels in cerebrospinal 
      fluid (CSF). Patients with AD and MCI had lower OSIT-J scores than did the HC. 
      The OSIT-J score was correlated with the MMSE, ADAS-J cog, TDAS, and Abeta42 
      results. There were no significant differences in the gustatory test scores among 
      the three groups. The gustatory test score was only correlated with the MMSE, 
      ADAS-J cog, and TDAS results. Olfactory function decreased in AD and MCI patients 
      and was associated with CSF biomarker levels and cognitive disorders. The results 
      suggest that olfactory function is impaired in early stage of AD. Gustatory 
      function was not correlated with CSF biomarkers, which suggests that it may not 
      be impaired in early stage of AD.
FAU - Kouzuki, Minoru
AU  - Kouzuki M
AUID- ORCID: 0000-0001-8122-3254
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan. 
      kouzuki@med.tottori-u.ac.jp.
FAU - Suzuki, Tetsuya
AU  - Suzuki T
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
FAU - Nagano, Masaya
AU  - Nagano M
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
FAU - Nakamura, Syouta
AU  - Nakamura S
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
FAU - Katsumata, Yuto
AU  - Katsumata Y
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
FAU - Takamura, Ayumi
AU  - Takamura A
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
FAU - Urakami, Katsuya
AU  - Urakami K
AD  - Department of Biological Regulation, School of Health Science, Faculty of 
      Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171111
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/cerebrospinal fluid/*complications
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Cognition Disorders/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Olfaction Disorders/diagnosis/*etiology
MH  - Peptide Fragments/cerebrospinal fluid
MH  - ROC Curve
MH  - Surveys and Questionnaires
MH  - Taste Disorders/diagnosis/*etiology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Cerebrospinal fluid biomarker
OT  - Cognitive function
OT  - Gustatory function
OT  - Mild cognitive impairment
OT  - Olfactory function
EDAT- 2017/11/13 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/11/13 06:00
PHST- 2017/05/06 00:00 [received]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/11/13 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/11/13 06:00 [entrez]
AID - 10.1007/s10072-017-3187-z [pii]
AID - 10.1007/s10072-017-3187-z [doi]
PST - ppublish
SO  - Neurol Sci. 2018 Feb;39(2):321-328. doi: 10.1007/s10072-017-3187-z. Epub 2017 Nov 
      11.