PMID- 29129626
OWN - NLM
STAT- MEDLINE
DCOM- 20180404
LR  - 20211204
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 52
DP  - 2018 Feb
TI  - Clinical significance of the serum biomarker index detection in children with 
      Henoch-Schonlein purpura.
PG  - 167-170
LID - S0009-9120(17)30879-2 [pii]
LID - 10.1016/j.clinbiochem.2017.11.006 [doi]
AB  - OBJECTIVE: To explore a panel of serum biomarkers for laboratory diagnosis of 
      pediatric Henoch-Schonlein purpura (HSP). METHODS: The blood white blood cells 
      (WBC) and serum levels of serum amyloid A (SAA), interleukin 6 (IL-6), 
      immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), 
      immunoglobulin E (IgE), C-reactive protein (CRP), complement component 3 (C3), 
      complement component 4 (C4), and ASO (anti-streptolysin O) were detected in 127 
      patients with Henoch-Schonlein purpura (HSP), 110 cases of septicemia patients, 
      and 121 healthy volunteers. The diagnostic ability of biomarkers selected from 
      HSP and septicemia patients was analyzed by ROC curve. By designing the 
      calculation model, the biomarker index was calculated for laboratory diagnosis of 
      HSP and differential diagnosis between HSP and septicemia. RESULTS: The levels of 
      serum WBC, CRP, IL-6 and SAA in the septicemia patients were significantly higher 
      than those in the control group (p<0.05). Compared with the healthy individuals, 
      serum levels of WBC, CRP, IL-6, SAA, IgA and IgM were significantly increased in 
      patients with HSP (p<0.05). The area under the curve (AUC) of SAA, IgA, IgM, WBC, 
      IL-6, and CRP in the patients with HSP was 0.964, 0.855, 0.849, 0.787, 0.765, and 
      0.622, respectively. The values of SAA, IgA, IgM, WBC, IL-6, and CRP in 
      septicemia patients were 0.700, 0.428, 0.689, 0.682, 0.891, and 0.853, 
      respectively. Biomarker index=SAA+IgA/4000+IgM/4000x0.4CRPmean valueCRPi(.) The 
      biomarker index in HSP patients was significantly higher than that of the healthy 
      controls. However, the biomarker index in septicemia patients was significantly 
      lower than the control. CONCLUSION: The biomarker index of HSP patients is higher 
      than that of the control group. While in the infectious disease represented by 
      septicemia, it is decreased. The detection of biomarker index could exclude the 
      interference of infection as the auxiliary examination to HSP patients.
CI  - Copyright (c) 2017 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Purevdorj, Narangerel
AU  - Purevdorj N
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China.
FAU - Mu, Yun
AU  - Mu Y
AD  - Department of Clinical Laboratory, Tianjin Children's Hospital, 238 Longyan Road, 
      Beichen District, Tianjin 300134, China.
FAU - Gu, Yajun
AU  - Gu Y
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China.
FAU - Zheng, Fang
AU  - Zheng F
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China.
FAU - Wang, Ran
AU  - Wang R
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China.
FAU - Yu, Jinwei
AU  - Yu J
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China.
FAU - Sun, Xuguo
AU  - Sun X
AD  - School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, 
      Hexi District, Tianjin 300203, China. Electronic address: sunxuguo@tmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171110
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Bacterial Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 0 (IL6 protein, human)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (Streptolysins)
RN  - 0 (streptolysin O)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Bacterial Proteins/analysis/blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - Female
MH  - Humans
MH  - IgA Vasculitis/blood/*diagnosis
MH  - Immunoglobulin A/analysis/blood
MH  - Immunoglobulin E/analysis/blood
MH  - Immunoglobulin G/analysis/blood
MH  - Interleukin-6/analysis/blood
MH  - Male
MH  - Sepsis/blood/diagnosis
MH  - Serum Amyloid A Protein/analysis
MH  - Streptolysins/analysis/blood
OTO - NOTNLM
OT  - Allergic purpura
OT  - Biomarker
OT  - Henoch-Schonlein purpura
OT  - ROC curve
OT  - Serum amyloid A
EDAT- 2017/11/14 06:00
MHDA- 2018/04/05 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/09/06 00:00 [received]
PHST- 2017/11/04 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/04/05 06:00 [medline]
PHST- 2017/11/14 06:00 [entrez]
AID - S0009-9120(17)30879-2 [pii]
AID - 10.1016/j.clinbiochem.2017.11.006 [doi]
PST - ppublish
SO  - Clin Biochem. 2018 Feb;52:167-170. doi: 10.1016/j.clinbiochem.2017.11.006. Epub 
      2017 Nov 10.