PMID- 29129676
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 665
DP  - 2018 Feb 5
TI  - Exercise enhances cognitive function and neurotrophin expression in the 
      hippocampus accompanied by changes in epigenetic programming in 
      senescence-accelerated mice.
PG  - 67-73
LID - S0304-3940(17)30921-7 [pii]
LID - 10.1016/j.neulet.2017.11.023 [doi]
AB  - Aerobic exercise is known to increase expression of neurotrophins, particularly 
      brain-derived neurotrophic factor (BDNF), in the hippocampus and to improve 
      cognitive function. Exercise exerts neuroprotective effects in the hippocampus by 
      inducing epigenetic changes, which play crucial roles in aging and 
      neurodegenerative diseases. Specifically, the activity levels of histone 
      acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone 
      acetylation and modulate gene transcription. The objective of the present study 
      was to assess the interactive effects of exercise and aging on cognitive 
      function, expression of neurotrophins (BDNF and neurotrophin-4) and their 
      receptors (tyrosine receptor kinase B and p75), and epigenetic regulations, 
      including the activity of HATs and HADCs in the hippocampus. We used the 
      senescence-accelerated mouse (SAM) model, specifically 13-month-old SAM resistant 
      1(SAMR1) and SAM prone 1 (SAMP1) lines. Mice were distributed into four groups 
      based on accelerated senescence and exercise status. Mice in the exercise groups 
      exercised on a treadmill for approximately 60min a day, 5days a week. Aerobic 
      exercise for 4 weeks improved cognitive function, accompanied by an increase in 
      BDNF expression and a decrease in p75 transcription in both SAMR1 and SAMP1. In 
      addition, the exercise regimen activated both HAT and HDAC in the hippocampus. 
      Therefore, the present study reveals that despite accelerated senescence, 
      long-term exercise improved cognitive function, upregulated the expression of 
      BDNF, and downregulated p75, a receptor involved in apoptotic signaling. 
      Furthermore, long-term exercise enhanced activity of both HAT and HDAC, which may 
      contribute to the transcriptional regulation underlying the improvement of 
      cognitive function.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Maejima, Hiroshi
AU  - Maejima H
AD  - Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido 
      University, Kita 12 Nishi 5, Kita-ku, Sapporo, 060-0812, Japan. Electronic 
      address: maeji@hs.hokudai.ac.jp.
FAU - Kanemura, Naohiko
AU  - Kanemura N
AD  - Department of Physical Therapy, Faculty of Health and Social Services, Saitama 
      Prefectural University, Sannomiya 820, Koshigaya, 343-8540, Japan.
FAU - Kokubun, Takanori
AU  - Kokubun T
AD  - Department of Physical Therapy, Faculty of Health and Social Services, Saitama 
      Prefectural University, Sannomiya 820, Koshigaya, 343-8540, Japan.
FAU - Murata, Kenji
AU  - Murata K
AD  - Department of Physical Therapy, Faculty of Health and Social Services, Saitama 
      Prefectural University, Sannomiya 820, Koshigaya, 343-8540, Japan.
FAU - Takayanagi, Kiyomi
AU  - Takayanagi K
AD  - Department of Physical Therapy, Faculty of Health and Social Services, Saitama 
      Prefectural University, Sannomiya 820, Koshigaya, 343-8540, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171110
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Cognition/*physiology
MH  - *Epigenesis, Genetic
MH  - Hippocampus/*metabolism
MH  - Histone Acetyltransferases/metabolism
MH  - Histone Deacetylases/*metabolism
MH  - Mice
MH  - Physical Conditioning, Animal/*physiology
MH  - Temporal Lobe/metabolism
OTO - NOTNLM
OT  - Aging
OT  - Epigenetics
OT  - Exercise
OT  - Hippocampus
OT  - Neurotrophin
EDAT- 2017/11/14 06:00
MHDA- 2018/11/14 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/06/23 00:00 [received]
PHST- 2017/11/07 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2017/11/14 06:00 [entrez]
AID - S0304-3940(17)30921-7 [pii]
AID - 10.1016/j.neulet.2017.11.023 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Feb 5;665:67-73. doi: 10.1016/j.neulet.2017.11.023. Epub 2017 
      Nov 10.