PMID- 29129846
OWN - NLM
STAT- MEDLINE
DCOM- 20180802
LR  - 20201019
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 243
IP  - 3
DP  - 2017 Nov
TI  - The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of 
      Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health 
      Study.
PG  - 159-164
LID - 10.1620/tjem.243.159 [doi]
AB  - Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role 
      in periodontitis and its polymorphisms might modulate the individual 
      susceptibility to periodontitis. Only a limited number of studies on the 
      association between IL18 single-nucleotide polymorphisms (SNPs) and the risk of 
      periodontitis have been realized, however. The aim of this case-control study 
      among young post-partum Japanese women (18 to 45 years) was to determine the 
      impact of SNPs, rs1946518 (-607 C/A) and rs187238 (-137G/C), on periodontitis. 
      The two SNPs may be located within a transcription factor-binding element, 
      thereby influencing transcription from the IL18 promoter. Subjects were 131 cases 
      who had at least one tooth with a probing pocket depth of >/= 4.0 mm and 1,017 
      periodontally healthy controls. Probing pocket depth measurements were performed 
      between 1 and 12 months post-partum. In this population, the A allele of 
      rs1946518 and the C allele of rs187238 are more common. After adjustment for age, 
      education, smoking, and use of an interdental brush, compared with subjects with 
      the AA or AC genotype of SNP rs1946518, those with the CC genotype had a 
      significantly reduced risk of periodontitis (adjusted odds ratio = 0.54, 95% 
      confidence interval = 0.29-0.97). No significant association was observed between 
      rs187238 and the risk of periodontitis. Our study did not reveal any evidence of 
      interaction between the IL18 polymorphisms and smoking. Our findings indicate 
      that the IL18 promoter SNP, rs1946518, is a potential risk factor of 
      periodontitis among young Japanese women.
FAU - Tanaka, Keiko
AU  - Tanaka K
AD  - Department of Epidemiology and Preventive Medicine, Ehime University Graduate 
      School of Medicine.
AD  - Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime 
      University Hospital.
FAU - Miyake, Yoshihiro
AU  - Miyake Y
AD  - Department of Epidemiology and Preventive Medicine, Ehime University Graduate 
      School of Medicine.
AD  - Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime 
      University Hospital.
FAU - Hanioka, Takashi
AU  - Hanioka T
AD  - Department of Preventive and Public Health Dentistry, Fukuoka Dental College.
FAU - Furukawa, Shinya
AU  - Furukawa S
AD  - Department of Epidemiology and Preventive Medicine, Ehime University Graduate 
      School of Medicine.
AD  - Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime 
      University Hospital.
FAU - Miyatake, Nobuyuki
AU  - Miyatake N
AD  - Department of Hygiene, Faculty of Medicine, Kagawa University.
FAU - Arakawa, Masashi
AU  - Arakawa M
AD  - Health Tourism Research Fields, Graduate School of Tourism Sciences, University 
      of the Ryukyus.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Japan/epidemiology
MH  - Maternal-Child Health Services
MH  - Middle Aged
MH  - Periodontitis/epidemiology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Postpartum Period
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - IL18
OT  - Japan
OT  - case-control study
OT  - periodontal disease
OT  - polymorphism
EDAT- 2017/11/14 06:00
MHDA- 2018/08/03 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/11/14 06:00 [entrez]
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/08/03 06:00 [medline]
AID - 10.1620/tjem.243.159 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2017 Nov;243(3):159-164. doi: 10.1620/tjem.243.159.