PMID- 29130137
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181113
IS  - 1741-0444 (Electronic)
IS  - 0140-0118 (Print)
IS  - 0140-0118 (Linking)
VI  - 56
IP  - 6
DP  - 2018 Jun
TI  - Assessment of the equivalent dipole layer source model in the reconstruction of 
      cardiac activation times on the basis of BSPMs produced by an anisotropic model 
      of the heart.
PG  - 1013-1025
LID - 10.1007/s11517-017-1715-x [doi]
AB  - Promising results have been reported in noninvasive estimation of cardiac 
      activation times (AT) using the equivalent dipole layer (EDL) source model in 
      combination with the boundary element method (BEM). However, the assumption of 
      equal anisotropy ratios in the heart that underlies the EDL model does not 
      reflect reality. In the present study, we quantify the errors of the nonlinear AT 
      imaging based on the EDL approximation. Nine different excitation patterns (sinus 
      rhythm and eight ectopic beats) were simulated with the monodomain model. Based 
      on the bidomain theory, the body surface potential maps (BSPMs) were calculated 
      for a realistic finite element volume conductor with an anisotropic heart model. 
      For the forward calculations, three cases of bidomain conductivity tensors in the 
      heart were considered: isotropic, equal, and unequal anisotropy ratios in the 
      intra- and extracellular spaces. In all inverse reconstructions, the EDL model 
      with BEM was employed: AT were estimated by solving the nonlinear optimization 
      problem with the initial guess provided by the fastest route algorithm. 
      Expectedly, the case of unequal anisotropy ratios resulted in larger localization 
      errors for almost all considered activation patterns. For the sinus rhythm, all 
      sites of early activation were correctly estimated with an optimal regularization 
      parameter being used. For the ectopic beats, all but one foci were correctly 
      classified to have either endo- or epicardial origin with an average localization 
      error of 20.4 mm for unequal anisotropy ratio. The obtained results confirm 
      validation studies and suggest that cardiac anisotropy might be neglected in 
      clinical applications of the considered EDL-based inverse procedure.
FAU - Janssen, Arno M
AU  - Janssen AM
AD  - The Netherlands Heart Institute, Utrecht, The Netherlands.
AD  - The Donders Institute for Brain, Cognition and Behaviour, Radboud University 
      Medical Centre, Nijmegen, The Netherlands.
FAU - Potyagaylo, Danila
AU  - Potyagaylo D
AUID- ORCID: 0000-0002-6613-1025
AD  - The Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), 
      Karlsruhe, Germany. danila.potyagaylo@kit.edu.
FAU - Dossel, Olaf
AU  - Dossel O
AD  - The Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), 
      Karlsruhe, Germany.
FAU - Oostendorp, Thom F
AU  - Oostendorp TF
AD  - The Netherlands Heart Institute, Utrecht, The Netherlands.
AD  - The Donders Institute for Brain, Cognition and Behaviour, Radboud University 
      Medical Centre, Nijmegen, The Netherlands.
LA  - eng
GR  - 10959/Dutch Technology Foundation STW/
GR  - DO 637/13-1/German Research Foundation (DFG)/
PT  - Journal Article
DEP - 20171113
PL  - United States
TA  - Med Biol Eng Comput
JT  - Medical & biological engineering & computing
JID - 7704869
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Anisotropy
MH  - Body Surface Potential Mapping/*methods
MH  - Heart/*physiology
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - *Models, Cardiovascular
MH  - Signal Processing, Computer-Assisted
PMC - PMC5978848
OTO - NOTNLM
OT  - Activation times imaging
OT  - Equivalent dipole layer
OT  - Fastest route algorithm
OT  - Forward and inverse problems of ECG
OT  - Influence of anisotropy
EDAT- 2017/11/14 06:00
MHDA- 2018/10/03 06:00
PMCR- 2017/11/13
CRDT- 2017/11/14 06:00
PHST- 2016/10/17 00:00 [received]
PHST- 2017/08/17 00:00 [accepted]
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2017/11/14 06:00 [entrez]
PHST- 2017/11/13 00:00 [pmc-release]
AID - 10.1007/s11517-017-1715-x [pii]
AID - 1715 [pii]
AID - 10.1007/s11517-017-1715-x [doi]
PST - ppublish
SO  - Med Biol Eng Comput. 2018 Jun;56(6):1013-1025. doi: 10.1007/s11517-017-1715-x. 
      Epub 2017 Nov 13.