PMID- 29130298
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20181115
IS  - 1827-1898 (Electronic)
IS  - 0031-0808 (Linking)
VI  - 60
IP  - 1
DP  - 2018 Mar
TI  - Role of microRNAs (miRNAs) in the pathophysiology of diabetes mellitus.
PG  - 25-28
LID - 10.23736/S0031-0808.17.03382-1 [doi]
AB  - Diabetes mellitus is becoming the critical problem among the entire world and it 
      is difficult to understand the molecular mechanism representing the concept of 
      diabetic pathology. Recently the knowledge of the involvement of genetics in type 
      2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration 
      towards the transcriptional activity of beta cells within the pancreas. This disease 
      becomes the leading cause of death, so it is necessary to study the molecular 
      pathogenesis, phenotypes, and characteristics to design the therapeutic 
      parameters. Here in this review role of miRNA is being illustrated as it plays a 
      crucial role in the pathogenesis, progression, and fate of beta cells of pancreas 
      regulating the insulin secretion. Here in this review, we try to include the 
      effects and pathophysiology of various miRNA in diabetes mellitus and on the 
      various sites of the human body.
FAU - Tiwari, Juhi
AU  - Tiwari J
AD  - School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 
      India.
FAU - Gupta, Gaurav
AU  - Gupta G
AD  - School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 
      India - gauravpharma25@gmail.com.
FAU - de Jesus Andreoli Pinto, Terezinha
AU  - de Jesus Andreoli Pinto T
AD  - Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Sharma, Rahul
AU  - Sharma R
AD  - School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 
      India.
FAU - Pabreja, Kavita
AU  - Pabreja K
AD  - School of Medicine and Public Health, University of Newcastle, Newcastle, 
      Australia.
FAU - Matta, Yogesh
AU  - Matta Y
AD  - School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 
      India.
FAU - Arora, Neha
AU  - Arora N
AD  - School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 
      India.
FAU - Mishra, Anurag
AU  - Mishra A
AD  - School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.
FAU - Sharma, Rakesh
AU  - Sharma R
AD  - School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.
FAU - Dua, Kamal
AU  - Dua K
AD  - Discipline of Pharmacy, Graduate School of Health, University of Technology 
      Sydney, Ultimo, Australia.
AD  - School of Pharmaceutical Sciences, Shoolini University, Solan, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171110
PL  - Italy
TA  - Panminerva Med
JT  - Panminerva medica
JID - 0421110
RN  - 0 (Insulin)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism/*physiopathology
MH  - Disease Progression
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin-Secreting Cells/metabolism
MH  - Mice
MH  - MicroRNAs/*genetics
MH  - Pancreas/physiology
MH  - Phenotype
MH  - Rats
MH  - Transcription, Genetic
EDAT- 2017/11/14 06:00
MHDA- 2018/11/16 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2017/11/14 06:00 [entrez]
AID - S0031-0808.17.03382-1 [pii]
AID - 10.23736/S0031-0808.17.03382-1 [doi]
PST - ppublish
SO  - Panminerva Med. 2018 Mar;60(1):25-28. doi: 10.23736/S0031-0808.17.03382-1. Epub 
      2017 Nov 10.