PMID- 29130666
OWN - NLM
STAT- MEDLINE
DCOM- 20190530
LR  - 20190530
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 48
IP  - 5
DP  - 2017 Sep
TI  - [Application of Chromosomal Microarray Analysis for Chromosomal Abnormalities of 
      Spontaneously Aborted Fetuses].
PG  - 732-735
AB  - OBJECTIVE: To evaluate the clinical significance of chromosomal microarry 
      analysis (CMA) for detection of chromosomal abnormalities in spontaneously 
      aborted fetuses. METHODS: Chorionic villi samples from 431 spontaneously aborted 
      fetuses were detected on the chromosomal abnormalities by CMA in our department 
      form September 2014 to April 2016. RESULTS: The overall success rate of CMA was 
      100%,and 283 cases were detected with abnormalities (65.67%). Of these 283 cases 
      with abnormal results,126 were common aneuploidies (trisomy 13,16,18,21,22 as 
      well as X and Y aneuploidies) (44.52%),72 were uncommon aneuploidies (25.44%),10 
      were composited aneuploidies (3.53%),9 were partial aneuploidies (3.18%),29 were 
      polyploidy (10.25%),4 were mosaicism (1.41%),31 were with multiple duplications 
      and deletions (10.96%),and 2 were microduplication/microdeletion syndromes. 
      CONCLUSION: CMA has great advantage for the detection of chromosomal 
      abnormalities in spontaneously aborted fetuses comparing with fluorescence in 
      situ hybridization (FISH). It is of great clinical significance for etiological 
      diagnosis of spontaneous abortion and guidance on reproduction.
FAU - Hu, Ting
AU  - Hu T
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Zhu, Hong-Mei
AU  - Zhu HM
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Zhang, Zhu
AU  - Zhang Z
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Wang, Jia-Min
AU  - Wang JM
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Zhang, Hai-Xia
AU  - Zhang HX
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Du, Ze
AU  - Du Z
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Li, Ling-Pingi
AU  - Li LP
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Wang, He
AU  - Wang H
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
FAU - Liu, Shan-Ling
AU  - Liu SL
AD  - Department of Obstetric and Gynecologic,West China Second University 
      Hospital,Sichuan University,Chengdu 610041,China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University),Ministry of Education,Chengdu 610041,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
SB  - IM
MH  - *Aborted Fetus
MH  - Chromosome Aberrations
MH  - Chromosome Disorders/*diagnosis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Microarray Analysis
MH  - Pregnancy
MH  - Prenatal Diagnosis
OTO - NOTNLM
OT  - Chromosomal abnormalities
OT  - Chromosomal microarray analysis
OT  - Spontaneous abortion
EDAT- 2017/11/14 06:00
MHDA- 2019/05/31 06:00
CRDT- 2017/11/14 06:00
PHST- 2017/11/14 06:00 [entrez]
PHST- 2017/11/14 06:00 [pubmed]
PHST- 2019/05/31 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Sep;48(5):732-735.