PMID- 29133640
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20191210
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 65
IP  - 11
DP  - 2017 Nov
TI  - Evaluation of spectral domain optical coherence tomography parameters in ocular 
      hypertension, preperimetric, and early glaucoma.
PG  - 1143-1150
LID - 10.4103/ijo.IJO_157_17 [doi]
AB  - PURPOSE: The objective of this study is to evaluate the diagnostic ability of 
      retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in 
      healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and 
      early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability 
      of spectral domain-optical coherence tomography (SD-OCT) parameters and risk 
      factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 
      OHT, 94 PPG, and 66 EG eyes) were analyzed. RNFL, macular, and ONH parameters 
      were measured with SD-OCT. The area under the receiver operating characteristic 
      curve (AUC) and sensitivity at 95% specificity was calculated. Logistic 
      regression analysis was used to determine the glaucoma risk factors. Receiver 
      operating characteristic regression analysis was used to evaluate the influence 
      of covariates on the diagnostic ability of parameters. RESULTS: In PPG patients, 
      parameters that had the largest AUC value were average RNFL thickness (0.83) and 
      rim volume (0.83). In EG patients, parameter that had the largest AUC value was 
      average RNFL thickness (0.98). The logistic regression analysis showed average 
      RNFL thickness was a risk factor for both PPG and EG. Diagnostic ability of 
      average RNFL and average ganglion cell complex thickness increased as disease 
      severity increased. Signal strength index did not affect diagnostic abilities. 
      Diagnostic ability of average RNFL and rim area increased as disc area increased. 
      CONCLUSION: When evaluating patients with glaucoma, patients at risk for 
      glaucoma, and healthy controls RNFL parameters deserve more attention in clinical 
      practice. Further studies are needed to fully understand the influence of 
      covariates on the diagnostic ability of OCT parameters.
FAU - Aydogan, Tugba
AU  - Aydogan T
AD  - Department of Glaucoma, Eye Clinic, Umraniye Training and Research Hospital, 
      Umraniye, Istanbul 34766, Turke.
FAU - Akcay, BetUl Ilkay Sezgin
AU  - Akcay BIS
AD  - Department of Glaucoma, Eye Clinic, Umraniye Training and Research Hospital, 
      Umraniye, Istanbul 34766, Turke.
FAU - Kardes, Esra
AU  - Kardes E
AD  - Department of Glaucoma, Eye Clinic, Umraniye Training and Research Hospital, 
      Umraniye, Istanbul 34766, Turke.
FAU - Ergin, Ahmet
AU  - Ergin A
AD  - Department of Glaucoma, Eye Clinic, Umraniye Training and Research Hospital, 
      Umraniye, Istanbul 34766, Turke.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Adult
MH  - Early Diagnosis
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ocular Hypertension/diagnosis
MH  - Optic Nerve Diseases/*diagnosis
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests
MH  - Visual Fields
PMC - PMC5700582
COIS- There are no conflicts of interest.
EDAT- 2017/11/15 06:00
MHDA- 2017/12/19 06:00
PMCR- 2017/11/01
CRDT- 2017/11/15 06:00
PHST- 2017/11/15 06:00 [entrez]
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2017_65_11_1143_218037 [pii]
AID - IJO-65-1143 [pii]
AID - 10.4103/ijo.IJO_157_17 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2017 Nov;65(11):1143-1150. doi: 10.4103/ijo.IJO_157_17.