PMID- 29133805
OWN - NLM
STAT- MEDLINE
DCOM- 20190723
LR  - 20190723
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Nov 13
TI  - Xanthine oxidoreductase activity is associated with serum uric acid and glycemic 
      control in hemodialysis patients.
PG  - 15416
LID - 10.1038/s41598-017-15419-0 [doi]
LID - 15416
AB  - Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal 
      source of reactive oxygen species. In the present study, we investigated factors 
      associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 +/- 10.9 years; 
      89 males and 74 females), using a newly established, highly-sensitive assay based 
      on [(13)C(2),(15)N(2)] xanthine and liquid chromatography/triple quadrupole mass 
      spectrometry. Plasma glucose and serum uric acid levels correlated significantly 
      and positively with plasma XOR-a. In multiple regression analyses, the presence 
      of type 2 diabetes mellitus (T2DM) and plasma glucose were associated 
      significantly, independently, and positively with plasma XOR-a. While serum uric 
      acid correlated significantly and positively with plasma XOR-a in hemodialysis 
      patients without T2DM, plasma glucose and serum glycated albumin, a new marker of 
      glycemic control in diabetic hemodialysis patients, correlated significantly and 
      positively with plasma XOR-a in those with T2DM. Multivariate analyses in those 
      with T2DM revealed that plasma glucose and serum glycated albumin were associated 
      significantly and independently with plasma XOR-a, and that serum uric acid was 
      associated significantly and independently with XOR-a in those without T2DM. Our 
      results suggested that glycemic control in hemodialysis patients may be important 
      in regard to a decrease in ROS induced by XOR.
FAU - Nakatani, Ayumi
AU  - Nakatani A
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
FAU - Nakatani, Shinya
AU  - Nakatani S
AUID- ORCID: 0000-0001-5302-3634
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
AD  - Departments of Nephrology, Osaka City University Graduate School of Medicine, 
      Osaka, Japan.
AD  - Departments of Nephrology, Ishikiriseiki Hospital, Osaka, Japan.
FAU - Ishimura, Eiji
AU  - Ishimura E
AD  - Departments of Nephrology, Osaka City University Graduate School of Medicine, 
      Osaka, Japan. ish@med.osaka-cu.ac.jp.
FAU - Murase, Takayo
AU  - Murase T
AD  - Departments of Radioisotope and Chemical Analysis Center, Laboratory Management, 
      Sanwa Kagaku Kenkyusho Co., Ltd, Nagoya, Aichi, Japan.
FAU - Nakamura, Takashi
AU  - Nakamura T
AD  - Department Pharmacological Study Group, Pharmaceutical Research Laboratories, 
      Sanwa Kagaku Kenkyusho Co., Ltd, Nagoya, Aichi, Japan.
FAU - Sakura, Mari
AU  - Sakura M
AD  - Departments of Nephrology, Ishikiriseiki Hospital, Osaka, Japan.
FAU - Tateishi, Yu
AU  - Tateishi Y
AD  - Departments of Nephrology, Ishikiriseiki Hospital, Osaka, Japan.
FAU - Tsuda, Akihiro
AU  - Tsuda A
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
FAU - Kurajoh, Masafumi
AU  - Kurajoh M
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
FAU - Mori, Katsuhito
AU  - Mori K
AD  - Departments of Nephrology, Osaka City University Graduate School of Medicine, 
      Osaka, Japan.
FAU - Emoto, Masanori
AU  - Emoto M
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
FAU - Inaba, Masaaki
AU  - Inaba M
AD  - Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka, Japan.
AD  - Departments of Nephrology, Osaka City University Graduate School of Medicine, 
      Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171113
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Reactive Oxygen Species)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 1.17.1.4 (Xanthine Dehydrogenase)
MH  - Aged
MH  - Animals
MH  - Biomarkers/blood/metabolism
MH  - Blood Glucose/analysis
MH  - Chromatography, Liquid
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/blood/complications/*therapy
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Reactive Oxygen Species/metabolism
MH  - *Renal Dialysis
MH  - Uric Acid/*blood
MH  - Xanthine Dehydrogenase/*blood/metabolism
PMC - PMC5684129
COIS- S.N., M.S., and Y.T. received a research grant from Sanwa Kagaku Kenkyusho Co., 
      Ltd. (Nagoya, Aichi, Japan). The other authors declare that they have no 
      conflicts of interest regarding this study.
EDAT- 2017/11/15 06:00
MHDA- 2019/07/25 06:00
PMCR- 2017/11/13
CRDT- 2017/11/15 06:00
PHST- 2017/06/08 00:00 [received]
PHST- 2017/10/26 00:00 [accepted]
PHST- 2017/11/15 06:00 [entrez]
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2017/11/13 00:00 [pmc-release]
AID - 10.1038/s41598-017-15419-0 [pii]
AID - 15419 [pii]
AID - 10.1038/s41598-017-15419-0 [doi]
PST - epublish
SO  - Sci Rep. 2017 Nov 13;7(1):15416. doi: 10.1038/s41598-017-15419-0.