PMID- 29135507
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 40
IP  - 5
DP  - 2018 May
TI  - Immunohistochemical and Fluorescence In Situ Hybridization Analysis of MYC in a 
      Series of 17 Cutaneous Angiosarcomas: A Single-Center Study.
PG  - 349-354
LID - 10.1097/DAD.0000000000001053 [doi]
AB  - Cutaneous angiosarcoma (AS) is an uncommon, aggressive sarcoma whose incidence is 
      rising because of the increasing use of radiation therapy, especially in breast 
      cancer. The few studies on the relevance of prognostic factors, such as MYC 
      status in cutaneous AS, have reported inconclusive findings, with some authors 
      reporting MYC amplification only in postirradiation and lymphedema-associated AS 
      and others reporting evidence of MYC amplification in idiopathic AS. We analyzed 
      17 cases of cutaneous AS (6 idiopathic AS, 10 postirradiation AS, and 1 
      lymphedema-associated AS) treated at our institute between 2000 and 2015. 
      Follow-up data were available in all cases. We compared the presence/absence of 
      MYC amplification by fluorescence in situ hybridization (FISH) and 
      immunohistochemical (IHC) MYC overexpression in the different AS subtypes. We 
      also investigated potential associations between MYC amplification and prognosis. 
      MYC amplification was observed by FISH in 6 of 14 informative cases. The positive 
      cases were all secondary AS (5 postirradiation AS and 1 lymphedema-associated 
      AS). IHC detected MYC overexpression in 8 of 15 informative cases (7 secondary AS 
      and 1 idiopathic AS). In conclusion, MYC amplification and MYC overexpression 
      were detected almost exclusively in secondary AS. No associations were found 
      between MYC amplification/overexpression and prognosis. We found MYC 
      amplification or overexpression in a similar proportion of the patients who died 
      and who were still alive at the end of the study. In the group of 9 patients who 
      died, MYC was detected by FISH in 4 cases and by IHC in 5. The corresponding 
      figures in the group of 6 patients still alive were 2 by FISH and 3 by IHC.
FAU - Requena, Celia
AU  - Requena C
AD  - Departments of Dermatology.
FAU - Rubio, Luis
AU  - Rubio L
AD  - Molecular Biology.
FAU - Lavernia, Javier
AU  - Lavernia J
AD  - Oncology, and.
FAU - Machado, Isidro
AU  - Machado I
AD  - Pathology, Instituto Valenciano de Oncologia, Valencia, Spain.
FAU - Llombart, Beatriz
AU  - Llombart B
AD  - Departments of Dermatology.
FAU - Sanmartin, Onofre
AU  - Sanmartin O
AD  - Departments of Dermatology.
FAU - Traves, Victor
AU  - Traves V
AD  - Pathology, Instituto Valenciano de Oncologia, Valencia, Spain.
FAU - Guillen, Carlos
AU  - Guillen C
AD  - Departments of Dermatology.
FAU - Cruz, Julia
AU  - Cruz J
AD  - Pathology, Instituto Valenciano de Oncologia, Valencia, Spain.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gene Amplification
MH  - Hemangiosarcoma/*genetics/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Radiation-Induced/*genetics
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Skin Neoplasms/*genetics/mortality/pathology
EDAT- 2017/11/15 06:00
MHDA- 2018/09/25 06:00
CRDT- 2017/11/15 06:00
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2017/11/15 06:00 [entrez]
AID - 10.1097/DAD.0000000000001053 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 2018 May;40(5):349-354. doi: 10.1097/DAD.0000000000001053.