PMID- 29135812 OWN - NLM STAT- MEDLINE DCOM- 20190712 LR - 20190712 IS - 1536-5166 (Electronic) IS - 1070-8022 (Linking) VI - 38 IP - 2 DP - 2018 Jun TI - Optic Nerve Head Drusen: The Relationship Between Intraocular Pressure and Optic Nerve Structure and Function. PG - 147-150 LID - 10.1097/WNO.0000000000000587 [doi] AB - OBJECTIVE: To determine whether at the time of diagnosis, the intraocular pressure (IOP) in patients with optic nerve head drusen (ONHD) correlates with the perimetric mean deviation (PMD) and the mean retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT). METHODS: This retrospective chart review included adults with ONHD from 2 academic medical centers. Inclusion criteria were age older than 18 years, definitive diagnosis of ONHD, measurement of IOP, and an automated visual field (VF) within 3 months of diagnosis. Exclusion criteria were unreliable VFs, use of IOP-lowering therapy, and visually significant ocular comorbidities. Data were collected from the initial visit. Age, IOP, method of diagnosis of ONHD, mean RNFL thickness, and PMD were recorded. Multiple and logistic regression models were used to control for potential confounders in statistical analyses. RESULTS: Chart review identified 623 patients, of which 146 patients met inclusion criteria. Mean age was 44.2 years (range: 19-82 years). Average PMD of 236 eyes was -5.22 dB (range, -31.2 to +1.21 dB). Mean IOP was 15.7 mm Hg (range: 6-24 mm Hg). Forty eyes (16.9%) underwent RNFL measurement using OCT; mean RNFL thickness was 79.9 mum (range: 43-117 mum). There was no statistically significant association between IOP and PMD (P = 0.13) or RNFL thickness (P = 0.65). Eyes with ocular hypertension tended to have less depressed PMD than those without (P= 0.031). Stratified analyses of visible and buried subgroups yielded similar results. CONCLUSIONS: Lowering IOP in patients with ONHD has been proposed as a means to prevent progression of optic neuropathy. Our study demonstrated that among predominately normotensive eyes, higher IOP was not associated with greater VF loss or thinner RNFL at the time of presentation. This suggests that lowering IOP may not be beneficial in preventing visual loss in normotensive eyes with ONHD. FAU - Nolan, Kaitlyn W AU - Nolan KW AD - Department of Ophthalmology and Visual Neurosciences (KWN, MSL, KCF, CMM), University of Minnesota School of Medicine, Minneapolis, Minnesota; and Department of Ophthalmology and Visual Sciences (RAJ, GPVS), Washington University School of Medicine, St. Louis, Missouri. FAU - Lee, Michael S AU - Lee MS FAU - Jalalizadeh, Rohan A AU - Jalalizadeh RA FAU - Firl, Kevin C AU - Firl KC FAU - Van Stavern, Gregory P AU - Van Stavern GP FAU - McClelland, Collin M AU - McClelland CM LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - J Neuroophthalmol JT - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society JID - 9431308 SB - IM CIN - J Neuroophthalmol. 2019 Mar;39(1):143. PMID: 30540634 CIN - J Neuroophthalmol. 2019 Mar;39(1):143-144. PMID: 30540636 CIN - Ophthalmologe. 2019 Dec;116(12):1134-1135. PMID: 31797115 MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Intraocular Pressure/*physiology MH - Male MH - Middle Aged MH - Nerve Fibers/physiology MH - Ocular Hypertension/physiopathology MH - Optic Disk Drusen/diagnosis/*physiopathology MH - Optic Nerve/*physiopathology MH - Retinal Ganglion Cells/pathology MH - Retrospective Studies MH - Tomography, Optical Coherence MH - Tonometry, Ocular MH - Vision Disorders/physiopathology MH - Visual Acuity MH - Visual Field Tests MH - Visual Fields/physiology MH - Young Adult EDAT- 2017/11/15 06:00 MHDA- 2019/07/13 06:00 CRDT- 2017/11/15 06:00 PHST- 2017/11/15 06:00 [pubmed] PHST- 2019/07/13 06:00 [medline] PHST- 2017/11/15 06:00 [entrez] AID - 10.1097/WNO.0000000000000587 [doi] PST - ppublish SO - J Neuroophthalmol. 2018 Jun;38(2):147-150. doi: 10.1097/WNO.0000000000000587.