PMID- 29136534
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20180904
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 619-620
DP  - 2018 Apr 1
TI  - Investigating the potential impact of polycyclic aromatic hydrocarbons (PAHs) and 
      polychlorinated biphenyls (PCBs) on gene biomarker expression and global DNA 
      methylation in loggerhead sea turtles (Caretta caretta) from the Adriatic Sea.
PG  - 49-57
LID - S0048-9697(17)33176-5 [pii]
LID - 10.1016/j.scitotenv.2017.11.118 [doi]
AB  - Polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are 
      priority contaminants that bioaccumulate through the food webs and affect the 
      biology of a variety of resident and migratory species, including sea turtles. 
      Few studies have evaluated toxicological biomarkers of exposure to PAHs and PCBs 
      in these animals. The present paper reports the results of an initial field study 
      to quantify the association between plasma concentrations of PAHs/PCBs and whole 
      blood cell expression of gene biomarkers in juvenile loggerhead sea turtles 
      (Caretta caretta) rescued along the Italian coasts of the northern and central 
      areas of the Adriatic Sea. While detectable levels of PAHs were found in all 
      plasma samples examined, only three PCB congeners (PCB52, PCB95, and PCB149) were 
      noted, with detection percentages ranging between 48% and 57%. A significant 
      correlation was found between 3 of the 6 gene biomarkers assessed (HSP60, CYP1A 
      and ERalpha) and plasma levels of some PAH congeners. In contrast, no significant 
      association between PCB burden and gene expression was observed. The global DNA 
      methylation levels were significantly and positively correlated with the 
      concentrations of most of the PAHs and only one of the PCB congeners (PCB52). The 
      relation between PAH concentration and gene expression in whole blood cells 
      suggests that these genes may respond to environmental contaminant exposure and 
      are promising candidates for the development of biomarkers for monitoring sea 
      turtle exposure to persistent organic pollutants (POPs).
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Cocci, Paolo
AU  - Cocci P
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Gentile III Da Varano, I-62032 Camerino, MC, Italy.
FAU - Mosconi, Gilberto
AU  - Mosconi G
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Gentile III Da Varano, I-62032 Camerino, MC, Italy.
FAU - Bracchetti, Luca
AU  - Bracchetti L
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Gentile III Da Varano, I-62032 Camerino, MC, Italy.
FAU - Nalocca, John Mark
AU  - Nalocca JM
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Gentile III Da Varano, I-62032 Camerino, MC, Italy.
FAU - Frapiccini, Emanuela
AU  - Frapiccini E
AD  - Institute of Marine Sciences (CBR-ISMAR), National Research Council, Largo Fiera 
      della Pesca 2, 60125 Ancona, AN, Italy.
FAU - Marini, Mauro
AU  - Marini M
AD  - Institute of Marine Sciences (CBR-ISMAR), National Research Council, Largo Fiera 
      della Pesca 2, 60125 Ancona, AN, Italy.
FAU - Caprioli, Giovanni
AU  - Caprioli G
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, I-62032 
      Camerino, MC, Italy.
FAU - Sagratini, Gianni
AU  - Sagratini G
AD  - School of Pharmacy, University of Camerino, Via Sant'Agostino 1, I-62032 
      Camerino, MC, Italy.
FAU - Palermo, Francesco Alessandro
AU  - Palermo FA
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Gentile III Da Varano, I-62032 Camerino, MC, Italy. Electronic address: 
      francesco.palermo@unicam.it.
LA  - eng
PT  - Journal Article
DEP - 20171112
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Biomarkers)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Biomarkers/analysis
MH  - *DNA Methylation
MH  - Environmental Monitoring
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Polycyclic Aromatic Hydrocarbons/*toxicity
MH  - Turtles/*genetics
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Adriatic Sea
OT  - Biomarkers
OT  - Caretta caretta
OT  - Gene transcription
OT  - PAH
OT  - PCB
EDAT- 2017/11/15 06:00
MHDA- 2018/09/05 06:00
CRDT- 2017/11/15 06:00
PHST- 2017/07/21 00:00 [received]
PHST- 2017/11/07 00:00 [revised]
PHST- 2017/11/09 00:00 [accepted]
PHST- 2017/11/15 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2017/11/15 06:00 [entrez]
AID - S0048-9697(17)33176-5 [pii]
AID - 10.1016/j.scitotenv.2017.11.118 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 Apr 1;619-620:49-57. doi: 
      10.1016/j.scitotenv.2017.11.118. Epub 2017 Nov 12.