PMID- 29137012
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 45
DP  - 2017 Nov
TI  - The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral 
      neuropathy in Type 2 diabetes mellitus.
PG  - e8289
LID - 10.1097/MD.0000000000008289 [doi]
LID - e8289
AB  - To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and 
      diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 
      newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, 
      including 397 T2DM patients without complication (DM group) as well as 160 T2DM 
      patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, 
      or chi test was applied to the data of the 2 groups, including the levels of 
      neutrophils and lymphocytes as well as the NLR values of peripheral blood and 
      other biochemistry indexes; Pearson correlation analysis was used to calculate 
      the correlation of NLR and detected factors; risk factors of DPN were estimated 
      via logistic regression analysis and multivariate analysis.The values of 
      triglyceride (TG), neutrophils, fasting insulin, urinary albumin, and 2 hour 
      postglucose in DPN group were significantly higher than those of the DM group, 
      whereas the number of lymphocytes of DPN group was considerably lower than that 
      of the DM group (P < .05 respectively); NLR values were remarkably higher in DPN 
      group compared with those of DM group (2.58 +/- 0.50 vs 2.18 +/- 0.61, P < .001); 
      logistic regression analysis showed that NLR (P = .002, OR = 4.960, 95% 
      CI = 1.843-13.349) was a risk factor of DPN. Multivariate logistic regression 
      analysis showed that DPN was independently related to NLR (P = .002, OR = 4.960, 
      95% CI = 1.843-13.349). The ROC curve analysis confirmed that the optimal cut-off 
      point, specificity, and sensitivity in diagnosing DPN by NLR were 2.13%, 48.1%, 
      and 81.3% respectively.Our results showed that NLR is significantly correlated 
      with DPN, which suggested that NLR may be an independent risk factor of DPN.
FAU - Xu, Tingting
AU  - Xu T
AD  - Zhujiang Hospital, Southern Medical University State Key Laboratory of 
      Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou 
      Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Weng, Zihua
AU  - Weng Z
FAU - Pei, Chu
AU  - Pei C
FAU - Yu, Siyuan
AU  - Yu S
FAU - Chen, Yating
AU  - Chen Y
FAU - Guo, Wenjie
AU  - Guo W
FAU - Wang, Xingzuo
AU  - Wang X
FAU - Luo, Peng
AU  - Luo P
FAU - Sun, Jia
AU  - Sun J
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Neuropathies/*blood
MH  - Female
MH  - Humans
MH  - Lymphocyte Count/*methods
MH  - Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - Neutrophils
MH  - ROC Curve
MH  - Risk Factors
PMC - PMC5690705
EDAT- 2017/11/16 06:00
MHDA- 2017/12/05 06:00
PMCR- 2017/11/10
CRDT- 2017/11/16 06:00
PHST- 2017/11/16 06:00 [entrez]
PHST- 2017/11/16 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2017/11/10 00:00 [pmc-release]
AID - 00005792-201711100-00008 [pii]
AID - MD-D-17-02531 [pii]
AID - 10.1097/MD.0000000000008289 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Nov;96(45):e8289. doi: 10.1097/MD.0000000000008289.